1a0b: Difference between revisions

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[[Image:1a0b.jpg|left|200px]]


{{Structure
==HISTIDINE-CONTAINING PHOSPHOTRANSFER DOMAIN OF ARCB FROM ESCHERICHIA COLI==
|PDB= 1a0b |SIZE=350|CAPTION= <scene name='initialview01'>1a0b</scene>, resolution 2.06&Aring;
<StructureSection load='1a0b' size='340' side='right'caption='[[1a0b]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
|SITE= <scene name='pdbsite=PHB:Phosphorylation+Site'>PHB</scene> and <scene name='pdbsite=ZNB:Zn+Binding+Site'>ZNB</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
<table><tr><td colspan='2'>[[1a0b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A0B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A0B FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a0b OCA], [https://pdbe.org/1a0b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a0b RCSB], [https://www.ebi.ac.uk/pdbsum/1a0b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a0b ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a0b OCA], [http://www.ebi.ac.uk/pdbsum/1a0b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a0b RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/ARCB_ECOLI ARCB_ECOLI] Member of the two-component regulatory system ArcB/ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His-717 and Asp-576.
 
== Evolutionary Conservation ==
'''HISTIDINE-CONTAINING PHOSPHOTRANSFER DOMAIN OF ARCB FROM ESCHERICHIA COLI'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==Overview==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a0/1a0b_consurf.spt"</scriptWhenChecked>
The histidine-containing phosphotransfer (HPt) domain is a novel protein module with an active histidine residue that mediates phosphotransfer reactions in the two-component signaling systems. A multistep phosphorelay involving the HPt domain has been suggested for these signaling pathways. The crystal structure of the HPt domain of the anaerobic sensor kinase ArcB has been determined at 2.06 A resolution. The domain consists of six alpha helices containing a four-helix bundle-folding. The pattern of sequence similarity of the HPt domains of ArcB and components in other signaling systems can be interpreted in light of the three-dimensional structure and supports the conclusion that the HPt domains have a common structural motif both in prokaryotes and eukaryotes.
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1A0B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A0B OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a0b ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
Insights into multistep phosphorelay from the crystal structure of the C-terminal HPt domain of ArcB., Kato M, Mizuno T, Shimizu T, Hakoshima T, Cell. 1997 Mar 7;88(5):717-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9054511 9054511]
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Hakoshima, T.]]
[[Category: Hakoshima T]]
[[Category: Kato, M.]]
[[Category: Kato M]]
[[Category: Mizuno, T.]]
[[Category: Mizuno T]]
[[Category: Shimizu, T.]]
[[Category: Shimizu T]]
[[Category: four-helix bundle]]
[[Category: histidine kinase]]
[[Category: phosphotransfer]]
[[Category: two-component system]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:30:30 2008''

Latest revision as of 09:26, 7 February 2024

HISTIDINE-CONTAINING PHOSPHOTRANSFER DOMAIN OF ARCB FROM ESCHERICHIA COLIHISTIDINE-CONTAINING PHOSPHOTRANSFER DOMAIN OF ARCB FROM ESCHERICHIA COLI

Structural highlights

1a0b is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.06Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ARCB_ECOLI Member of the two-component regulatory system ArcB/ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His-717 and Asp-576.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1a0b, resolution 2.06Å

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