190d: Difference between revisions

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[[Image:190d.gif|left|200px]]


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==Crystal structure of a four-stranded intercalated DNA: d(C4)==
The line below this paragraph, containing "STRUCTURE_190d", creates the "Structure Box" on the page.
<StructureSection load='190d' size='340' side='right'caption='[[190d]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[190d]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=190D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=190D FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=190d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=190d OCA], [https://pdbe.org/190d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=190d RCSB], [https://www.ebi.ac.uk/pdbsum/190d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=190d ProSAT]</span></td></tr>
{{STRUCTURE_190d|  PDB=190d |  SCENE= }}
</table>
 
__TOC__
'''CRYSTAL STRUCTURE OF A FOUR-STRANDED INTERCALATED DNA: D(C4)'''
</StructureSection>
 
[[Category: Large Structures]]
 
[[Category: Cai L]]
==Overview==
[[Category: Chen L]]
The crystal structure of d(C4) solved at 2.3-A resolution reveals a four-stranded molecule composed of two interdigitated or intercalated duplexes. The duplexes are held together by hemiprotonated cytosine-cytosine base pairs and are parallel stranded, but the two duplexes point in opposite directions. The molecule has a slow right-handed twist of 12.4 degrees between covalently linked cytosine base pairs, and the base stacking distance is 3.1 A. This is in general agreement with the NMR studies. A biological role for DNA in this conformation is suggested.
[[Category: Rich A]]
 
[[Category: Zhang X]]
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=190D OCA].  
 
==Reference==
Crystal structure of a four-stranded intercalated DNA: d(C4)., Chen L, Cai L, Zhang X, Rich A, Biochemistry. 1994 Nov 22;33(46):13540-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7947764 7947764]
[[Category: Cai, L.]]
[[Category: Chen, L.]]
[[Category: Rich, A.]]
[[Category: Zhang, X.]]
[[Category: Base intercalated]]
[[Category: Mismatched]]
[[Category: Parallel-stranded tetraplex]]
[[Category: Quadruple helix]]
[[Category: U-dna]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 09:34:52 2008''

Latest revision as of 09:26, 7 February 2024

Crystal structure of a four-stranded intercalated DNA: d(C4)Crystal structure of a four-stranded intercalated DNA: d(C4)

Structural highlights

190d is a 8 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

190d, resolution 1.80Å

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