Tumor necrosis factor: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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-<StructureSection load='2az5' size='350' side='right' caption='Structure of human tumor necrosis factor complex with inhibitor (PDB entry [[2az5]])' scene=''>
+<StructureSection load='' size='350' side='right' caption='Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry [[2az5]])' scene='55/551212/Cv/1'>
+== Function ==
+'''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis.  '''TNFα''' is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome).  It is involved in the regulation of the immune cells<ref>PMID:11514191</ref>.  '''TNFβ''' is inhibited by interleukin 10.  TNF is a transmembrane homotrimer.  The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]). See also [[TRAIL]] and [[Molecular Playground/TRAIL]].
+== Relevance ==
+TNF is studied as both a target and a therapeutic in malignant diseases<ref>PMID:19343034</ref>.
+== Structural highlights ==
+The biological assembly of human tumor necrosis factor is <scene name='55/551212/Cv/4'>homotetramer</scene> (PDB entry [[2az5]]). <scene name='55/551212/Cv/5'>Inhibitor binding site</scene>.
-'''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis.  TNFα is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome).  It is involved in the regulation of the immune cells.  TNF is a transmembrane homotrimer.  The soluble TNF is produced by cleavage by the metalloprotease TNF alpha converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]).
 == 3D Structures of tumor necrosis factor ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+[[Tumor necrosis factor 3D structures]]
-===TNF alpha===
-[[1tnf]] – hTNF – human   <BR />
+== References ==
-[[2tun]], [[1a8m]], [[4tsv]], [[5tsw]], [[2e7e]], [[2zjc]], [[2zpx]] – hTNF (mutant)   <BR />
+<references/>
-[[2tnf]] – TNF – mouse   <BR />
+</StructureSection>
-[[2az5]] – hTNF + inhibitor   <BR />
+[[Category:Topic Page]]
-[[3it8]] – hTNF + poxvirus 2L protein   <BR />
-[[3l9j]] – hTNF + antagonist   <BR />
-[[3alq]] – hTNF (mutant) + TNF receptor   <BR />
-[[4g3y]] – hTNF + antibody  <BR />