2yne: Difference between revisions
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==Plasmodium vivax N-myristoyltransferase in complex with a benzothiophene inhibitor== | ==Plasmodium vivax N-myristoyltransferase in complex with a benzothiophene inhibitor== | ||
<StructureSection load='2yne' size='340' side='right' caption='[[2yne]], [[Resolution|resolution]] 1.72Å' scene=''> | <StructureSection load='2yne' size='340' side='right'caption='[[2yne]], [[Resolution|resolution]] 1.72Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2yne]] is a 3 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2yne]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YNE FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NHW:2-OXOPENTADECYL-COA'>NHW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YNE:2-(3-PIPERIDIN-4-YLOXY-1-BENZOTHIOPHEN-2-YL)-5-[(1,3,5-TRIMETHYLPYRAZOL-4-YL)METHYL]-1,3,4-OXADIAZOLE'>YNE</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NHW:2-OXOPENTADECYL-COA'>NHW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YNE:2-(3-PIPERIDIN-4-YLOXY-1-BENZOTHIOPHEN-2-YL)-5-[(1,3,5-TRIMETHYLPYRAZOL-4-YL)METHYL]-1,3,4-OXADIAZOLE'>YNE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yne OCA], [https://pdbe.org/2yne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yne RCSB], [https://www.ebi.ac.uk/pdbsum/2yne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yne ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/A5K1A2_PLAVS A5K1A2_PLAVS] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).[RuleBase:RU000586] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 18: | Line 18: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2yne" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Plasmodium vivax]] | ||
[[Category: Bottrill | [[Category: Bottrill AR]] | ||
[[Category: Brannigan | [[Category: Brannigan JA]] | ||
[[Category: Broncel | [[Category: Broncel M]] | ||
[[Category: Clough | [[Category: Clough B]] | ||
[[Category: Grainger | [[Category: Grainger M]] | ||
[[Category: Heal | [[Category: Heal WP]] | ||
[[Category: Holder | [[Category: Holder AA]] | ||
[[Category: Leatherbarrow | [[Category: Leatherbarrow RJ]] | ||
[[Category: Mann | [[Category: Mann D]] | ||
[[Category: Rackham | [[Category: Rackham MD]] | ||
[[Category: Serwa | [[Category: Serwa RA]] | ||
[[Category: Tate | [[Category: Tate EW]] | ||
[[Category: Wilkinson | [[Category: Wilkinson AJ]] | ||
[[Category: Wright | [[Category: Wright MH]] | ||