2yjw: Difference between revisions

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-==TRICYCLIC SERIES OF HSP90 INHIBITORS==
-<StructureSection load='2yjw' size='340' side='right' caption='[[2yjw]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
+==Tricyclic series of Hsp90 inhibitors==
+<StructureSection load='2yjw' size='340' side='right'caption='[[2yjw]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2yjw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YJW FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2yjw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YJW FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YJW:4-(5-METHYL-4-PHENYLISOXAZOL-3-YL)BENZENE-1,3-DIOL'>YJW</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.61&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yi0|2yi0]], [[2bsm|2bsm]], [[1osf|1osf]], [[2wi3|2wi3]], [[2ye4|2ye4]], [[2yi5|2yi5]], [[2ye5|2ye5]], [[2bz5|2bz5]], [[2yei|2yei]], [[2ccs|2ccs]], [[2yeg|2yeg]], [[1uyi|1uyi]], [[1yc3|1yc3]], [[1uyf|1uyf]], [[2ye3|2ye3]], [[2byi|2byi]], [[2yi6|2yi6]], [[2vci|2vci]], [[2wi1|2wi1]], [[2xjx|2xjx]], [[2xdk|2xdk]], [[2fwz|2fwz]], [[2xjg|2xjg]], [[1uyh|1uyh]], [[2fwy|2fwy]], [[1uye|1uye]], [[1uyl|1uyl]], [[2xab|2xab]], [[2yeh|2yeh]], [[2xht|2xht]], [[1uy7|1uy7]], [[2xhr|2xhr]], [[2yef|2yef]], [[2byh|2byh]], [[2wi5|2wi5]], [[2cdd|2cdd]], [[1uy9|1uy9]], [[1yes|1yes]], [[1byq|1byq]], [[2yi7|2yi7]], [[1uy8|1uy8]], [[2wi4|2wi4]], [[2bug|2bug]], [[2yeb|2yeb]], [[2uwd|2uwd]], [[2ye7|2ye7]], [[2wi7|2wi7]], [[2xhx|2xhx]], [[2bt0|2bt0]], [[2yej|2yej]], [[1yer|1yer]], [[2yec|2yec]], [[2xdu|2xdu]], [[1uyg|1uyg]], [[2ccu|2ccu]], [[2xds|2xds]], [[2xdx|2xdx]], [[2xk2|2xk2]], [[2xjj|2xjj]], [[1uyd|1uyd]], [[2wi2|2wi2]], [[2xdl|2xdl]], [[1uy6|1uy6]], [[2yee|2yee]], [[2ye2|2ye2]], [[2vcj|2vcj]], [[1yc4|1yc4]], [[2ye9|2ye9]], [[2c2l|2c2l]], [[1uyk|1uyk]], [[2cct|2cct]], [[2wi6|2wi6]], [[2yea|2yea]], [[1yc1|1yc1]], [[2ye6|2ye6]], [[2yed|2yed]], [[1uyc|1uyc]], [[1yet|1yet]], [[2jjc|2jjc]], [[2yjx|2yjx]], [[2ye8|2ye8]], [[2yk9|2yk9]], [[2yki|2yki]], [[2yke|2yke]], [[2ykc|2ykc]], [[2yk2|2yk2]], [[2ykb|2ykb]], [[2ykj|2ykj]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YJW:4-(5-METHYL-4-PHENYLISOXAZOL-3-YL)BENZENE-1,3-DIOL'>YJW</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yjw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yjw RCSB], [http://www.ebi.ac.uk/pdbsum/2yjw PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yjw OCA], [https://pdbe.org/2yjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yjw RCSB], [https://www.ebi.ac.uk/pdbsum/2yjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yjw ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 15: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2yjw" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Heat Shock Protein structures|Heat Shock Protein structures]]
 == References ==
 <references/>
@@ Line 20: / Line 27: @@
 </StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Dupuy, A.]]
+[[Category: Large Structures]]
-[[Category: Vallee, F.]]
+[[Category: Dupuy A]]
-[[Category: Chaperone]]
+[[Category: Vallee F]]
-[[Category: Inhibition]]