2y6d: Difference between revisions

==The Discovery of MMP7 Inhibitors Exploiting a Novel Selectivity Trigger==

<StructureSection load='2y6d' size='340' side='right'caption='[[2y6d]], [[Resolution|resolution]] 1.60&Aring;' scene=''>

<table><tr><td colspan='2'>[[2y6d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y6D FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TQJ:N-[(2S)-1-[4-(5-BROMOPYRIDIN-2-YL)PIPERAZIN-1-YL]SULFONYL-5-PYRIMIDIN-2-YL-PENTAN-2-YL]-N-HYDROXY-METHANAMIDE'>TQJ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y6d OCA], [https://pdbe.org/2y6d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y6d RCSB], [https://www.ebi.ac.uk/pdbsum/2y6d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y6d ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/MMP7_HUMAN MMP7_HUMAN] Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.<ref>PMID:2550050</ref>  

*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Edman K]]

[[Category: Furber M]]

[[Category: Hemsley P]]

[[Category: Johansson C]]

[[Category: Pairaudeau G]]

[[Category: Petersen J]]

[[Category: Stocks M]]

[[Category: Tervo A]]

[[Category: Ward A]]

[[Category: Wells E]]

[[Category: Wissler L]]