7zj3: Difference between revisions
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New page: '''Unreleased structure''' The entry 7zj3 is ON HOLD Authors: Esposito, D., Garza-Garcia, A., Fraser, J., Rittinger, K. Description: Structure of TRIM2 RING domain in complex with UBE2... |
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==Structure of TRIM2 RING domain in complex with UBE2D1~Ub conjugate== | |||
<StructureSection load='7zj3' size='340' side='right'caption='[[7zj3]], [[Resolution|resolution]] 2.53Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7zj3]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZJ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZJ3 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.53Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zj3 OCA], [https://pdbe.org/7zj3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zj3 RCSB], [https://www.ebi.ac.uk/pdbsum/7zj3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zj3 ProSAT]</span></td></tr> | ||
[[Category: Esposito | </table> | ||
[[Category: Fraser | == Disease == | ||
[[Category: Garza-Garcia | [https://www.uniprot.org/uniprot/TRIM2_HUMAN TRIM2_HUMAN] Charcot-Marie-Tooth disease type 2R. The disease is caused by variants affecting the gene represented in this entry. | ||
== Function == | |||
[https://www.uniprot.org/uniprot/TRIM2_HUMAN TRIM2_HUMAN] UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.[UniProtKB:Q9ESN6] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Esposito D]] | |||
[[Category: Fraser J]] | |||
[[Category: Garza-Garcia A]] | |||
[[Category: Rittinger K]] | |||
Latest revision as of 16:32, 1 February 2024
Structure of TRIM2 RING domain in complex with UBE2D1~Ub conjugateStructure of TRIM2 RING domain in complex with UBE2D1~Ub conjugate
Structural highlights
DiseaseTRIM2_HUMAN Charcot-Marie-Tooth disease type 2R. The disease is caused by variants affecting the gene represented in this entry. FunctionTRIM2_HUMAN UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.[UniProtKB:Q9ESN6] |
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