7r4o: Difference between revisions

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-'''Unreleased structure'''
-The entry 7r4o is ON HOLD
+==Structure of human hydroxyacid oxidase 1 bound with 2-((4H-1,2,4-triazol-3-yl)thio)-1-(4-(3-chlorophenyl)piperazin-1-yl)ethan-1-one==
+<StructureSection load='7r4o' size='340' side='right'caption='[[7r4o]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7r4o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R4O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R4O FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=I2W:2-((4H-1,2,4-triazol-3-yl)thio)-1-(4-(3-chlorophenyl)piperazin-1-yl)ethan-1-one'>I2W</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r4o OCA], [https://pdbe.org/7r4o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r4o RCSB], [https://www.ebi.ac.uk/pdbsum/7r4o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r4o ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HAOX1_HUMAN HAOX1_HUMAN] Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.
-Authors: Mackinnon, S., Bezerra, G.A., Krojer, T., Bradley, A.R., Talon, R., Brandeo-Neto, J., Douangamath, A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Oppermann, U., Brennan, P.E., Yue, W.W.
+==See Also==
+*[[Glycolate oxidase 3D structures|Glycolate oxidase 3D structures]]
-Description: Structure of human hydroxyacid oxidase 1 bound with 2-((4H-1,2,4-triazol-3-yl)thio)-1-(4-(3-chlorophenyl)piperazin-1-yl)ethan-1-one
+__TOC__
-[[Category: Unreleased Structures]]
+</StructureSection>
-[[Category: Brandeo-Neto, J]]
+[[Category: Homo sapiens]]
-[[Category: Mackinnon, S]]
+[[Category: Large Structures]]
-[[Category: Bradley, A.R]]
+[[Category: Arrowsmith CH]]
-[[Category: Arrowsmith, C.H]]
+[[Category: Bezerra GA]]
-[[Category: Talon, R]]
+[[Category: Bountra C]]
-[[Category: Brennan, P.E]]
+[[Category: Bradley AR]]
-[[Category: Oppermann, U]]
+[[Category: Brandeo-Neto J]]
-[[Category: Bezerra, G.A]]
+[[Category: Brennan PE]]
-[[Category: Edwards, A]]
+[[Category: Douangamath A]]
-[[Category: Douangamath, A]]
+[[Category: Edwards A]]
-[[Category: Krojer, T]]
+[[Category: Krojer T]]
-[[Category: Yue, W.W]]
+[[Category: Mackinnon S]]
-[[Category: Von Delft, F]]
+[[Category: Oppermann U]]
-[[Category: Bountra, C]]
+[[Category: Talon R]]
+[[Category: Yue WW]]
+[[Category: Von Delft F]]