7r4o: Difference between revisions
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New page: '''Unreleased structure''' The entry 7r4o is ON HOLD Authors: Mackinnon, S., Bezerra, G.A., Krojer, T., Bradley, A.R., Talon, R., Brandeo-Neto, J., Douangamath, A., von Delft, F., Arrow... |
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==Structure of human hydroxyacid oxidase 1 bound with 2-((4H-1,2,4-triazol-3-yl)thio)-1-(4-(3-chlorophenyl)piperazin-1-yl)ethan-1-one== | |||
<StructureSection load='7r4o' size='340' side='right'caption='[[7r4o]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7r4o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R4O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R4O FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=I2W:2-((4H-1,2,4-triazol-3-yl)thio)-1-(4-(3-chlorophenyl)piperazin-1-yl)ethan-1-one'>I2W</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r4o OCA], [https://pdbe.org/7r4o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r4o RCSB], [https://www.ebi.ac.uk/pdbsum/7r4o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r4o ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HAOX1_HUMAN HAOX1_HUMAN] Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate. | |||
==See Also== | |||
*[[Glycolate oxidase 3D structures|Glycolate oxidase 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Arrowsmith CH]] | ||
[[Category: | [[Category: Bezerra GA]] | ||
[[Category: | [[Category: Bountra C]] | ||
[[Category: Brennan | [[Category: Bradley AR]] | ||
[[Category: | [[Category: Brandeo-Neto J]] | ||
[[Category: | [[Category: Brennan PE]] | ||
[[Category: | [[Category: Douangamath A]] | ||
[[Category: | [[Category: Edwards A]] | ||
[[Category: | [[Category: Krojer T]] | ||
[[Category: | [[Category: Mackinnon S]] | ||
[[Category: | [[Category: Oppermann U]] | ||
[[Category: | [[Category: Talon R]] | ||
[[Category: Yue WW]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 16:26, 1 February 2024
Structure of human hydroxyacid oxidase 1 bound with 2-((4H-1,2,4-triazol-3-yl)thio)-1-(4-(3-chlorophenyl)piperazin-1-yl)ethan-1-oneStructure of human hydroxyacid oxidase 1 bound with 2-((4H-1,2,4-triazol-3-yl)thio)-1-(4-(3-chlorophenyl)piperazin-1-yl)ethan-1-one
Structural highlights
FunctionHAOX1_HUMAN Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate. See Also |
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