7qw6: Difference between revisions

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'''Unreleased structure'''


The entry 7qw6 is ON HOLD  until Jan 24 2024
==Adenine-specific DNA methyltransferase M.BseCI complexed with AdoHcy and cognate hemimethylated DNA duplex==
<StructureSection load='7qw6' size='340' side='right'caption='[[7qw6]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7qw6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QW6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6MA:N6-METHYL-DEOXY-ADENOSINE-5-MONOPHOSPHATE'>6MA</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qw6 OCA], [https://pdbe.org/7qw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qw6 RCSB], [https://www.ebi.ac.uk/pdbsum/7qw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qw6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MTC1_GEOSE MTC1_GEOSE] A gamma subtype methylase, recognizes the double-stranded sequence 5'-ATCGAT-3', methylation on A-5 on both strands, and protects the DNA from cleavage by the BanIII endonuclease.<ref>PMID:12654995</ref>


Authors: Mitsikas, D.A., Kouyianou, K., Kotsifaki, D., Providaki, M., Bouriotis, V., Glykos, N.M., Kokkinidis, M.
==See Also==
 
*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
Description: Adenine-specific DNA methyltransferase M.BseCI complexed with AdoHcy and cognate hemimethylated DNA duplex
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Bouriotis, V]]
__TOC__
[[Category: Glykos, N.M]]
</StructureSection>
[[Category: Kotsifaki, D]]
[[Category: Geobacillus stearothermophilus]]
[[Category: Kokkinidis, M]]
[[Category: Large Structures]]
[[Category: Mitsikas, D.A]]
[[Category: Bouriotis V]]
[[Category: Providaki, M]]
[[Category: Glykos NM]]
[[Category: Kouyianou, K]]
[[Category: Kokkinidis M]]
[[Category: Kotsifaki D]]
[[Category: Kouyianou K]]
[[Category: Mitsikas DA]]
[[Category: Providaki M]]

Latest revision as of 16:23, 1 February 2024

Adenine-specific DNA methyltransferase M.BseCI complexed with AdoHcy and cognate hemimethylated DNA duplexAdenine-specific DNA methyltransferase M.BseCI complexed with AdoHcy and cognate hemimethylated DNA duplex

Structural highlights

7qw6 is a 3 chain structure with sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MTC1_GEOSE A gamma subtype methylase, recognizes the double-stranded sequence 5'-ATCGAT-3', methylation on A-5 on both strands, and protects the DNA from cleavage by the BanIII endonuclease.[1]

See Also

References

  1. ↑ Roberts RJ, Belfort M, Bestor T, Bhagwat AS, Bickle TA, Bitinaite J, Blumenthal RM, Degtyarev SKh, Dryden DT, Dybvig K, Firman K, Gromova ES, Gumport RI, Halford SE, Hattman S, Heitman J, Hornby DP, Janulaitis A, Jeltsch A, Josephsen J, Kiss A, Klaenhammer TR, Kobayashi I, Kong H, Kruger DH, Lacks S, Marinus MG, Miyahara M, Morgan RD, Murray NE, Nagaraja V, Piekarowicz A, Pingoud A, Raleigh E, Rao DN, Reich N, Repin VE, Selker EU, Shaw PC, Stein DC, Stoddard BL, Szybalski W, Trautner TA, Van Etten JL, Vitor JM, Wilson GG, Xu SY. A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes. Nucleic Acids Res. 2003 Apr 1;31(7):1805-12. PMID:12654995

7qw6, resolution 2.40Å

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