7q3o: Difference between revisions

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'''Unreleased structure'''


The entry 7q3o is ON HOLD
==Structure of CDX1 bound to hydroxymethylated DNA==
 
<StructureSection load='7q3o' size='340' side='right'caption='[[7q3o]], [[Resolution|resolution]] 2.78&Aring;' scene=''>
Authors: Morgunova, E., Yin, Y., Popov, A., Taipale, J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7q3o]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q3O FirstGlance]. <br>
Description: Structure of CDX1 bound to hydroxymethylated DNA
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.78&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5HC:2-DEOXY-5-(HYDROXYMETHYL)CYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>5HC</scene></td></tr>
[[Category: Taipale, J]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q3o OCA], [https://pdbe.org/7q3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q3o RCSB], [https://www.ebi.ac.uk/pdbsum/7q3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q3o ProSAT]</span></td></tr>
[[Category: Popov, A]]
</table>
[[Category: Morgunova, E]]
== Function ==
[[Category: Yin, Y]]
[https://www.uniprot.org/uniprot/CDX1_HUMAN CDX1_HUMAN] Plays a role in transcriptional regulation (PubMed:24623306). Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the PRKD1 promoter in colorectal cancer (CRC) cells (PubMed:24623306). Could play a role in the terminal differentiation of the intestine.<ref>PMID:24623306</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Morgunova E]]
[[Category: Popov A]]
[[Category: Taipale J]]
[[Category: Yin Y]]

Latest revision as of 16:13, 1 February 2024

Structure of CDX1 bound to hydroxymethylated DNAStructure of CDX1 bound to hydroxymethylated DNA

Structural highlights

7q3o is a 12 chain structure with sequence from Homo sapiens and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.78Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CDX1_HUMAN Plays a role in transcriptional regulation (PubMed:24623306). Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the PRKD1 promoter in colorectal cancer (CRC) cells (PubMed:24623306). Could play a role in the terminal differentiation of the intestine.[1]

References

  1. ↑ Serra RW, Fang M, Park SM, Hutchinson L, Green MR. A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. Elife. 2014 Mar 12;3:e02313. doi: 10.7554/eLife.02313. PMID:24623306 doi:http://dx.doi.org/10.7554/eLife.02313

7q3o, resolution 2.78Å

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OCA
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