7q3o: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
-The entry 7q3o is ON HOLD
+==Structure of CDX1 bound to hydroxymethylated DNA==
+<StructureSection load='7q3o' size='340' side='right'caption='[[7q3o]], [[Resolution|resolution]] 2.78&Aring;' scene=''>
-Authors: Morgunova, E., Yin, Y., Popov, A., Taipale, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7q3o]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q3O FirstGlance]. <br>
-Description: Structure of CDX1 bound to hydroxymethylated DNA
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.78&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5HC:2-DEOXY-5-(HYDROXYMETHYL)CYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>5HC</scene></td></tr>
-[[Category: Taipale, J]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q3o OCA], [https://pdbe.org/7q3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q3o RCSB], [https://www.ebi.ac.uk/pdbsum/7q3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q3o ProSAT]</span></td></tr>
-[[Category: Popov, A]]
+</table>
-[[Category: Morgunova, E]]
+== Function ==
-[[Category: Yin, Y]]
+[https://www.uniprot.org/uniprot/CDX1_HUMAN CDX1_HUMAN] Plays a role in transcriptional regulation (PubMed:24623306). Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the PRKD1 promoter in colorectal cancer (CRC) cells (PubMed:24623306). Could play a role in the terminal differentiation of the intestine.<ref>PMID:24623306</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Synthetic construct]]
+[[Category: Morgunova E]]
+[[Category: Popov A]]
+[[Category: Taipale J]]
+[[Category: Yin Y]]