7q37: Difference between revisions

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-'''Unreleased structure'''
-The entry 7q37 is ON HOLD  until Paper Publication
+==Crystal structure of proton pump MAR rhodopsin pressurized with krypton==
+<StructureSection load='7q37' size='340' side='right'caption='[[7q37]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7q37]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candidatus_Actinomarina_minuta Candidatus Actinomarina minuta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q37 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q37 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene>, <scene name='pdbligand=HEX:HEXANE'>HEX</scene>, <scene name='pdbligand=KR:KRYPTON'>KR</scene>, <scene name='pdbligand=LFA:EICOSANE'>LFA</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q37 OCA], [https://pdbe.org/7q37 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q37 RCSB], [https://www.ebi.ac.uk/pdbsum/7q37 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q37 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/S5DM51_9ACTN S5DM51_9ACTN]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+In this work we examine how small hydrophobic molecules such as inert gases interact with membrane proteins (MPs) at a molecular level. High pressure atmospheres of argon and krypton were used to produce noble gas derivatives of crystals of three well studied MPs (two different proton pumps and a sodium light-driven ion pump). The structures obtained using X-ray crystallography showed that the vast majority of argon and krypton binding sites were located on the outer hydrophobic surface of the MPs - a surface usually accommodating hydrophobic chains of annular lipids (which are known structural and functional determinants for MPs). In conformity with these results, supplementary in silico molecular dynamics (MD) analysis predicted even greater numbers of argon and krypton binding positions on MP surface within the bilayer. These results indicate a potential importance of such interactions, particularly as related to the phenomenon of noble gas-induced anaesthesia.
-Authors: Melnikov, I., Rulev, M., Astashkin, R., Kovalev, K., Carpentier, P., Gordeliy, V., Popov, A.
+High-pressure crystallography shows noble gas intervention into protein-lipid interaction and suggests a model for anaesthetic action.,Melnikov I, Orekhov P, Rulev M, Kovalev K, Astashkin R, Bratanov D, Ryzhykau Y, Balandin T, Bukhdruker S, Okhrimenko I, Borshchevskiy V, Bourenkov G, Mueller-Dieckmann C, van der Linden P, Carpentier P, Leonard G, Gordeliy V, Popov A Commun Biol. 2022 Apr 14;5(1):360. doi: 10.1038/s42003-022-03233-y. PMID:35422073<ref>PMID:35422073</ref>
-Description: Crystal structure of proton pump MAR rhodopsin pressurized with krypton
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Astashkin, R]]
+<div class="pdbe-citations 7q37" style="background-color:#fffaf0;"></div>
-[[Category: Popov, A]]
-[[Category: Melnikov, I]]
+==See Also==
-[[Category: Gordeliy, V]]
+*[[Bacteriorhodopsin 3D structures|Bacteriorhodopsin 3D structures]]
-[[Category: Rulev, M]]
+== References ==
-[[Category: Kovalev, K]]
+<references/>
-[[Category: Carpentier, P]]
+__TOC__
+</StructureSection>
+[[Category: Candidatus Actinomarina minuta]]
+[[Category: Large Structures]]
+[[Category: Astashkin R]]
+[[Category: Carpentier P]]
+[[Category: Gordeliy V]]
+[[Category: Kovalev K]]
+[[Category: Melnikov I]]
+[[Category: Popov A]]
+[[Category: Rulev M]]