7osn: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[7osn]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Micromonospora_sp._Rc5 Micromonospora sp. Rc5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OSN FirstGlance]. <br> | <table><tr><td colspan='2'>[[7osn]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Micromonospora_sp._Rc5 Micromonospora sp. Rc5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OSN FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7osn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7osn OCA], [https://pdbe.org/7osn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7osn RCSB], [https://www.ebi.ac.uk/pdbsum/7osn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7osn ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7osn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7osn OCA], [https://pdbe.org/7osn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7osn RCSB], [https://www.ebi.ac.uk/pdbsum/7osn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7osn ProSAT]</span></td></tr> | ||
</table> | </table> | ||
Latest revision as of 15:55, 1 February 2024
IRED361 from Micromonospora sp. in complex with NADP+IRED361 from Micromonospora sp. in complex with NADP+
Structural highlights
FunctionPublication Abstract from PubMedThe development of efficient and sustainable methods for the synthesis of nitrogen heterocycles is an important goal for the chemical industry. In particular, substituted chiral piperidines are prominent targets due to their prevalence in medicinally relevant compounds and their precursors. A potential biocatalytic approach to the synthesis of this privileged scaffold would be the asymmetric dearomatization of readily assembled activated pyridines. However, nature is yet to yield a suitable biocatalyst specifically for this reaction. Here, by combining chemical synthesis and biocatalysis, we present a general chemo-enzymatic approach for the asymmetric dearomatization of activated pyridines for the preparation of substituted piperidines with precise stereochemistry. The key step involves a stereoselective one-pot amine oxidase/ene imine reductase cascade to convert N-substituted tetrahydropyridines to stereo-defined 3- and 3,4-substituted piperidines. This chemo-enzymatic approach has proved useful for key transformations in the syntheses of antipsychotic drugs Preclamol and OSU-6162, as well as for the preparation of two important intermediates in synthetic routes of the ovarian cancer monotherapeutic Niraparib. Synthesis of Stereoenriched Piperidines via Chemo-Enzymatic Dearomatization of Activated Pyridines.,Harawa V, Thorpe TW, Marshall JR, Sangster JJ, Gilio AK, Pirvu L, Heath RS, Angelastro A, Finnigan JD, Charnock SJ, Nafie JW, Grogan G, Whitehead RC, Turner NJ J Am Chem Soc. 2022 Nov 23;144(46):21088-21095. doi: 10.1021/jacs.2c07143. Epub , 2022 Nov 9. PMID:36350999[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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