7nml: Difference between revisions

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'''Unreleased structure'''


The entry 7nml is ON HOLD  until Paper Publication
==Galectin-1 in complex with 4-Amino-6-chloro-1,3-benzenedisulfonamide==
<StructureSection load='7nml' size='340' side='right'caption='[[7nml]], [[Resolution|resolution]] 1.43&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7nml]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NML FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.43&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=I7B:4-AMINO-6-CHLOROBENZENE-1,3-DISULFONAMIDE'>I7B</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nml OCA], [https://pdbe.org/7nml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nml RCSB], [https://www.ebi.ac.uk/pdbsum/7nml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nml ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref>


Authors: Grimm, C., Bechold, J., Seibel, J.
==See Also==
 
*[[Galectin 3D structures|Galectin 3D structures]]
Description: Galectin-1 in complex with 4-Amino-6-chloro-1,3-benzenedisulfonamide
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Seibel, J]]
__TOC__
[[Category: Bechold, J]]
</StructureSection>
[[Category: Grimm, C]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bechold J]]
[[Category: Grimm C]]
[[Category: Seibel J]]

Latest revision as of 15:36, 1 February 2024

Galectin-1 in complex with 4-Amino-6-chloro-1,3-benzenedisulfonamideGalectin-1 in complex with 4-Amino-6-chloro-1,3-benzenedisulfonamide

Structural highlights

7nml is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.43Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LEG1_HUMAN May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.[1] [2]

See Also

References

  1. ↑ He J, Baum LG. Presentation of galectin-1 by extracellular matrix triggers T cell death. J Biol Chem. 2004 Feb 6;279(6):4705-12. Epub 2003 Nov 14. PMID:14617626 doi:10.1074/jbc.M311183200
  2. ↑ Nishi N, Abe A, Iwaki J, Yoshida H, Itoh A, Shoji H, Kamitori S, Hirabayashi J, Nakamura T. Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1. Glycobiology. 2008 Dec;18(12):1065-73. Epub 2008 Sep 16. PMID:18796645 doi:10.1093/glycob/cwn089

7nml, resolution 1.43Å

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