7bl9: Difference between revisions

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-'''Unreleased structure'''
-The entry 7bl9 is ON HOLD
+==BAZ2A bromodomain in complex with GSK2801 chemical probe==
+<StructureSection load='7bl9' size='340' side='right'caption='[[7bl9]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7bl9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BL9 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3WQ:1-{1-[2-(METHYLSULFONYL)PHENYL]-7-PROPOXYINDOLIZIN-3-YL}ETHANONE'>3WQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bl9 OCA], [https://pdbe.org/7bl9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bl9 RCSB], [https://www.ebi.ac.uk/pdbsum/7bl9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bl9 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/BAZ2A_HUMAN BAZ2A_HUMAN] Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).
-Authors: Dalle Vedove, A., Cazzanelli, G., Caflisch, A., Lolli, G.
+==See Also==
+*[[Bromodomain adjacent to zinc finger 3D structures|Bromodomain adjacent to zinc finger 3D structures]]
-Description: BAZ2A bromodomain in complex with GSK2801 chemical probe
+__TOC__
-[[Category: Unreleased Structures]]
+</StructureSection>
-[[Category: Dalle Vedove, A]]
+[[Category: Homo sapiens]]
-[[Category: Lolli, G]]
+[[Category: Large Structures]]
-[[Category: Cazzanelli, G]]
+[[Category: Caflisch A]]
-[[Category: Caflisch, A]]
+[[Category: Cazzanelli G]]
+[[Category: Dalle Vedove A]]
+[[Category: Lolli G]]