7av9: Difference between revisions
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New page: '''Unreleased structure''' The entry 7av9 is ON HOLD Authors: Krojer, T., Talon, R., Fairhead, M., Szykowska, A., Burgess-Brown, N.A., Brennan, P.E., Arrowsmith, C.H., Edwards, A.M., Bo... |
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==Crystal Structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in space group C2== | |||
<StructureSection load='7av9' size='340' side='right'caption='[[7av9]], [[Resolution|resolution]] 1.23Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7av9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AV9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AV9 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.23Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7av9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7av9 OCA], [https://pdbe.org/7av9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7av9 RCSB], [https://www.ebi.ac.uk/pdbsum/7av9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7av9 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PHIP_HUMAN PHIP_HUMAN] Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.<ref>PMID:12242307</ref> <ref>PMID:21834987</ref> | |||
==See Also== | |||
*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Arrowsmith CH]] | ||
[[Category: | [[Category: Bountra C]] | ||
[[Category: | [[Category: Brennan PE]] | ||
[[Category: | [[Category: Burgess-Brown NA]] | ||
[[Category: | [[Category: Edwards AM]] | ||
[[Category: Von Delft | [[Category: Fairhead M]] | ||
[[Category: Krojer T]] | |||
[[Category: Szykowska A]] | |||
[[Category: Talon R]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 15:16, 1 February 2024
Crystal Structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in space group C2Crystal Structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in space group C2
Structural highlights
FunctionPHIP_HUMAN Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.[1] [2] See AlsoReferences
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