6zx2: Difference between revisions
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==OMPD-domain of human UMPS in complex with 6-carboxamido-UMP at 1.2 Angstroms resolution== | |||
<StructureSection load='6zx2' size='340' side='right'caption='[[6zx2]], [[Resolution|resolution]] 1.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6zx2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZX2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PRO:PROLINE'>PRO</scene>, <scene name='pdbligand=QRT:[(2~{R},3~{S},4~{R},5~{R})-5-[6-aminocarbonyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl+dihydrogen+phosphate'>QRT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zx2 OCA], [https://pdbe.org/6zx2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zx2 RCSB], [https://www.ebi.ac.uk/pdbsum/6zx2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zx2 ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[https://omim.org/entry/258900 258900]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN] | |||
==See Also== | |||
*[[Uridine 5'-monophosphate synthase 3D structures|Uridine 5'-monophosphate synthase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Rindfleisch | __TOC__ | ||
[[Category: Schimdt | </StructureSection> | ||
[[Category: Tittmann | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Rindfleisch S]] | |||
[[Category: Schimdt T]] | |||
[[Category: Tittmann K]] | |||
Latest revision as of 14:59, 1 February 2024
OMPD-domain of human UMPS in complex with 6-carboxamido-UMP at 1.2 Angstroms resolutionOMPD-domain of human UMPS in complex with 6-carboxamido-UMP at 1.2 Angstroms resolution
Structural highlights
DiseaseUMPS_HUMAN Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:258900. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.[1] FunctionSee AlsoReferences |
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