8osb: Difference between revisions
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New page: '''Unreleased structure''' The entry 8osb is ON HOLD Authors: Morgunova, E., Kim, S., Popov, A., Wysocka, J., Taipale, J. Description: TWIST1-TCF4-ALX4 complex on specific DNA [[Catego... |
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==TWIST1-TCF4-ALX4 complex on specific DNA== | |||
<StructureSection load='8osb' size='340' side='right'caption='[[8osb]], [[Resolution|resolution]] 2.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8osb]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OSB FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8osb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8osb OCA], [https://pdbe.org/8osb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8osb RCSB], [https://www.ebi.ac.uk/pdbsum/8osb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8osb ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Kim | == Disease == | ||
[[Category: Popov | [https://www.uniprot.org/uniprot/ITF2_HUMAN ITF2_HUMAN] Autosomal dominant non-syndromic intellectual disability;Fuchs endothelial corneal dystrophy;Pitt-Hopkins syndrome;Schizophrenia;Primary sclerosing cholangitis. The disease is caused by mutations affecting the gene represented in this entry. | ||
[[Category: | == Function == | ||
[[Category: Wysocka | [https://www.uniprot.org/uniprot/ITF2_HUMAN ITF2_HUMAN] Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Kim S]] | |||
[[Category: Morgunova E]] | |||
[[Category: Popov A]] | |||
[[Category: Taipale J]] | |||
[[Category: Wysocka J]] | |||
Latest revision as of 14:43, 1 February 2024
TWIST1-TCF4-ALX4 complex on specific DNATWIST1-TCF4-ALX4 complex on specific DNA
Structural highlights
DiseaseITF2_HUMAN Autosomal dominant non-syndromic intellectual disability;Fuchs endothelial corneal dystrophy;Pitt-Hopkins syndrome;Schizophrenia;Primary sclerosing cholangitis. The disease is caused by mutations affecting the gene represented in this entry. FunctionITF2_HUMAN Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. |
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