5q1f: Difference between revisions

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 ==Ligand binding to FARNESOID-X-RECEPTOR==
-<StructureSection load='5q1f' size='340' side='right' caption='[[5q1f]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+<StructureSection load='5q1f' size='340' side='right'caption='[[5q1f]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5q1f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Q1F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Q1F FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5q1f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Q1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Q1F FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9NJ:trans-4-({(2S)-2-cyclohexyl-2-[2-(2,6-dimethoxypyridin-3-yl)-5-fluoro-1H-benzimidazol-1-yl]acetyl}amino)cyclohexane-1-carboxylic+acid'>9NJ</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NR1H4, BAR, FXR, HRR1, RIP14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9NJ:trans-4-({(2S)-2-cyclohexyl-2-[2-(2,6-dimethoxypyridin-3-yl)-5-fluoro-1H-benzimidazol-1-yl]acetyl}amino)cyclohexane-1-carboxylic+acid'>9NJ</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5q1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5q1f OCA], [http://pdbe.org/5q1f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5q1f RCSB], [http://www.ebi.ac.uk/pdbsum/5q1f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5q1f ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5q1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5q1f OCA], [https://pdbe.org/5q1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5q1f RCSB], [https://www.ebi.ac.uk/pdbsum/5q1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5q1f ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN]] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
+[https://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 19: @@
 </div>
 <div class="pdbe-citations 5q1f" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Bile acid receptor 3D structures|Bile acid receptor 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Benz, J]]
+[[Category: Large Structures]]
-[[Category: Burger, D]]
+[[Category: Benz J]]
-[[Category: Burley, S K]]
+[[Category: Burger D]]
-[[Category: Joseph, C]]
+[[Category: Burley SK]]
-[[Category: Kuhn, B]]
+[[Category: Joseph C]]
-[[Category: Rudolph, M G]]
+[[Category: Kuhn B]]
-[[Category: Ruf, A]]
+[[Category: Rudolph MG]]
-[[Category: Shao, C]]
+[[Category: Ruf A]]
-[[Category: Thoma, R]]
+[[Category: Shao C]]
-[[Category: Yang, H]]
+[[Category: Thoma R]]
-[[Category: D3r]]
+[[Category: Yang H]]
-[[Category: Docking]]
-[[Category: Fxr]]
-[[Category: Transcription]]