6zde: Difference between revisions
New page: '''Unreleased structure''' The entry 6zde is ON HOLD until Dec 14 2021 Authors: Badran, M.J., Heine, A., Klebe, G. Description: 17beta-hydroxysteroid dehydrogenase type 14 variant S205... |
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The | ==17beta-hydroxysteroid dehydrogenase type 14 variant S205 in complex with pentafluorophenol== | ||
<StructureSection load='6zde' size='340' side='right'caption='[[6zde]], [[Resolution|resolution]] 1.87Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6zde]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZDE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZDE FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=QFZ:2,3,4,5,6-pentakis(fluoranyl)phenol'>QFZ</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zde OCA], [https://pdbe.org/6zde PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zde RCSB], [https://www.ebi.ac.uk/pdbsum/6zde PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zde ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DHB14_HUMAN DHB14_HUMAN] Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).<ref>PMID:17067289</ref> | |||
==See Also== | |||
*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: Heine | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Badran MJ]] | |||
[[Category: Heine A]] | |||
[[Category: Klebe G]] | |||