6txj: Difference between revisions
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<StructureSection load='6txj' size='340' side='right'caption='[[6txj]], [[Resolution|resolution]] 2.17Å' scene=''> | <StructureSection load='6txj' size='340' side='right'caption='[[6txj]], [[Resolution|resolution]] 2.17Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6txj]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[6txj]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TXJ FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LFA:EICOSANE'>LFA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.17Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LFA:EICOSANE'>LFA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6txj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6txj OCA], [https://pdbe.org/6txj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6txj RCSB], [https://www.ebi.ac.uk/pdbsum/6txj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6txj ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6txj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6txj OCA], [https://pdbe.org/6txj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6txj RCSB], [https://www.ebi.ac.uk/pdbsum/6txj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6txj ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/Q9X0L2_THEMA Q9X0L2_THEMA] Iron storage protein (By similarity).[RuleBase:RU361145] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 6txj" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6txj" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Ferritin 3D structures|Ferritin 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Thermotoga maritima MSB8]] | ||
[[Category: Biela | [[Category: Biela AP]] | ||
[[Category: Chakraborti | [[Category: Chakraborti S]] | ||
[[Category: Grudnik | [[Category: Grudnik P]] | ||
[[Category: Heddle | [[Category: Heddle J]] | ||
[[Category: Kumar | [[Category: Kumar M]] | ||
[[Category: Wilk | [[Category: Wilk P]] | ||
Latest revision as of 16:11, 24 January 2024
Crystal structure of thermotoga maritima A42V E65D FerritinCrystal structure of thermotoga maritima A42V E65D Ferritin
Structural highlights
FunctionQ9X0L2_THEMA Iron storage protein (By similarity).[RuleBase:RU361145] Publication Abstract from PubMedCage forming proteins have numerous potential applications in biomedicine and biotechnology, where the iron storage ferritin is a widely used example. However, controlling ferritin cage assembly/disassembly remains challenging, typically requiring extreme conditions incompatible with many desirable cargoes, particularly for more fragile biopharmaceuticals. Recently, a ferritin from the hyperthermophile bacterium Thermotoga maritima (TmFtn) has been shown to have reversible assembly under mild conditions, offering greater potential biocompatibility in terms of cargo access and encapsulation. Like Archeoglobus fulgidus ferritin (AfFtn), TmFtn forms 24mer cages mediated by metal ions (Mg2+). We have solved the crystal structure of the wild type TmFtn and several mutants displaying different assembly/disassembly properties. These data combined with other biophysical studies allow us to suggest candidate interfacial amino acids crucial in controlling assembly. This work deepens our understanding of how these ferritin complexes assemble and is a useful step towards production of triggerable ferritins in which these properties can be finely designed and controlled. A single residue can modulate nanocage assembly in salt dependent ferritin.,Kumar M, Markiewicz-Mizera J, Janna Olmos JD, Wilk P, Grudnik P, Biela AP, Jemiola-Rzeminska M, Gorecki A, Chakraborti S, Heddle JG Nanoscale. 2021 Jul 15;13(27):11932-11942. doi: 10.1039/d1nr01632f. PMID:34195748[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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