6ti3: Difference between revisions
New page: '''Unreleased structure''' The entry 6ti3 is ON HOLD Authors: Petrillo, G., Hernandez, K., Bujons, J., Clapes, P., Uson, I. Description: SHMTSth Tyr55Thr in complex with D-Ser both as ... |
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==Apo-SHMT from Streptococcus thermophilus Tyr55Ser variant in complex with D-Threonine== | |||
<StructureSection load='6ti3' size='340' side='right'caption='[[6ti3]], [[Resolution|resolution]] 1.96Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ti3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_thermophilus Streptococcus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TI3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TI3 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTH:D-THREONINE'>DTH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ti3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ti3 OCA], [https://pdbe.org/6ti3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ti3 RCSB], [https://www.ebi.ac.uk/pdbsum/6ti3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ti3 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GLYA_STRT1 GLYA_STRT1] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | |||
==See Also== | |||
*[[Serine hydroxymethyltransferase 3D structures|Serine hydroxymethyltransferase 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Bujons | [[Category: Streptococcus thermophilus]] | ||
[[Category: | [[Category: Bujons J]] | ||
[[Category: Hernandez | [[Category: Clapes P]] | ||
[[Category: | [[Category: Hernandez K]] | ||
[[Category: Petrillo G]] | |||
[[Category: Uson I]] | |||