6t78: Difference between revisions

<table><tr><td colspan='2'>[[6t78]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T78 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6T78 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.504&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6t78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t78 OCA], [https://pdbe.org/6t78 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6t78 RCSB], [https://www.ebi.ac.uk/pdbsum/6t78 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6t78 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/SOX11_HUMAN SOX11_HUMAN] Coffin-Siris syndrome. The disease is caused by mutations affecting the gene represented in this entry.

[https://www.uniprot.org/uniprot/SOX11_HUMAN SOX11_HUMAN] Transcription factor that acts as a transcriptional activator (PubMed:24886874). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity). Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (By similarity). Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity).[UniProtKB:Q7M6Y2]<ref>PMID:24886874</ref>  

[[Category: Homo sapiens]]

[[Category: Cramer P]]

[[Category: Dienemann C]]

[[Category: Dodonova SO]]

[[Category: Taipale J]]

[[Category: Zhu F]]