6t6f: Difference between revisions

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New page: '''Unreleased structure''' The entry 6t6f is ON HOLD Authors: Sorrell, F., Kraemer, A., Butterworth, S., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Knapp, S., Structural Genomics Con...
 
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'''Unreleased structure'''


The entry 6t6f is ON HOLD
==Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) bound to compound 8 (CS275)==
<StructureSection load='6t6f' size='340' side='right'caption='[[6t6f]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6t6f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6T6F FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MMW:2-[(3~{S})-3-azanylpiperidin-1-yl]-4-[[3-(trifluoromethyl)phenyl]amino]pyrimidine-5-carboxamide'>MMW</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6t6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t6f OCA], [https://pdbe.org/6t6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6t6f RCSB], [https://www.ebi.ac.uk/pdbsum/6t6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6t6f ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KCC1D_HUMAN KCC1D_HUMAN] Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.<ref>PMID:11050006</ref> <ref>PMID:15840691</ref> <ref>PMID:16324104</ref> <ref>PMID:17056143</ref>


Authors: Sorrell, F., Kraemer, A., Butterworth, S., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
==See Also==
 
*[[Calcium/calmodulin dependent protein kinase 3D structures|Calcium/calmodulin dependent protein kinase 3D structures]]
Description: Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) bound to compound 8 (CS275)
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Butterworth, S]]
__TOC__
[[Category: Knapp, S]]
</StructureSection>
[[Category: Edwards, A.M]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C.H]]
[[Category: Large Structures]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Sorrell, F]]
[[Category: Butterworth S]]
[[Category: Kraemer, A]]
[[Category: Edwards AM]]
[[Category: Knapp S]]
[[Category: Kraemer A]]
[[Category: Sorrell F]]

Latest revision as of 15:55, 24 January 2024

Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) bound to compound 8 (CS275)Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) bound to compound 8 (CS275)

Structural highlights

6t6f is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.97Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KCC1D_HUMAN Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.[1] [2] [3] [4]

See Also

References

  1. ↑ Verploegen S, Lammers JW, Koenderman L, Coffer PJ. Identification and characterization of CKLiK, a novel granulocyte Ca(++)/calmodulin-dependent kinase. Blood. 2000 Nov 1;96(9):3215-23. PMID:11050006
  2. ↑ Verploegen S, Ulfman L, van Deutekom HW, van Aalst C, Honing H, Lammers JW, Koenderman L, Coffer PJ. Characterization of the role of CaMKI-like kinase (CKLiK) in human granulocyte function. Blood. 2005 Aug 1;106(3):1076-83. Epub 2005 Apr 19. PMID:15840691 doi:http://dx.doi.org/10.1182/blood-2004-09-3755
  3. ↑ Sakagami H, Kamata A, Nishimura H, Kasahara J, Owada Y, Takeuchi Y, Watanabe M, Fukunaga K, Kondo H. Prominent expression and activity-dependent nuclear translocation of Ca2+/calmodulin-dependent protein kinase Idelta in hippocampal neurons. Eur J Neurosci. 2005 Dec;22(11):2697-707. PMID:16324104 doi:http://dx.doi.org/10.1111/j.1460-9568.2005.04463.x
  4. ↑ Kamata A, Sakagami H, Tokumitsu H, Owada Y, Fukunaga K, Kondo H. Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth. Neurosci Res. 2007 Jan;57(1):86-97. Epub 2006 Oct 23. PMID:17056143 doi:http://dx.doi.org/10.1016/j.neures.2006.09.013

6t6f, resolution 1.97Å

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