6hol: Difference between revisions

<table><tr><td colspan='2'>[[6hol]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HOL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HOL FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GABARAPL1, GEC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hol OCA], [http://pdbe.org/6hol PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hol RCSB], [http://www.ebi.ac.uk/pdbsum/6hol PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hol ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/GBRL1_HUMAN GBRL1_HUMAN]] Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles.<ref>PMID:16431922</ref> <ref>PMID:20404487</ref> [[http://www.uniprot.org/uniprot/BAKOR_HUMAN BAKOR_HUMAN]] Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604). Modulates the hepatic lipid metabolism (By similarity).[UniProtKB:Q8CDJ3]<ref>PMID:18843052</ref> <ref>PMID:19050071</ref> <ref>PMID:19270696</ref> <ref>PMID:20713597</ref> <ref>PMID:23878393</ref> <ref>PMID:25686604</ref> 

[[Category: Human]]

[[Category: Bhujbal, Z]]

[[Category: Birgisdottir, A B]]

[[Category: Evjen, G]]

[[Category: Johansen, T]]

[[Category: Lamark, T]]

[[Category: Lee, R]]

[[Category: Mouilleron, S]]

[[Category: Reilly, N O]]

[[Category: Sjottem, E]]

[[Category: Tooze, S]]

[[Category: Wirth, M]]

[[Category: Zhang, W]]

[[Category: Signaling protein]]