Ethambutol: Difference between revisions
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<StructureSection load='' size='340' side='right' caption=' | <StructureSection load='' size='340' side='right' caption='Ethambutol' scene='10/1022091/Cv/1'> | ||
Ethambutol (EMB, E) is a medication primarily used to treat tuberculosis.<ref name="a4">[https://www.drugs.com/monograph/ethambutol.html "Ethambutol Hydrochloride".] drugs.com. The American Society of Health-System Pharmacists. Archived from the original on 5 June 2016. Retrieved 10 December 2016.</ref> It is usually given in combination with other tuberculosis medications, such as isoniazid, rifampicin and [[pyrazinamide]].<ref name="a5">Stuart MC, Kouimtzi M, Hill SR, eds. (2009). WHO Model Formulary 2008. World Health Organization. pp. 136, 138, 588, 603. hdl:10665/44053. ISBN 9789241547659.</ref> It may also be used to treat Mycobacterium avium complex, and Mycobacterium kansasii.<ref name="a4">[https://www.drugs.com/monograph/ethambutol.html "Ethambutol Hydrochloride".] drugs.com. The American Society of Health-System Pharmacists. Archived from the original on 5 June 2016. Retrieved 10 December 2016.</ref> See also [https://en.wikipedia.org/wiki/Ethambutol Ethambutol]. | Ethambutol (EMB, E) is a medication primarily used to treat tuberculosis.<ref name="a4">[https://www.drugs.com/monograph/ethambutol.html "Ethambutol Hydrochloride".] drugs.com. The American Society of Health-System Pharmacists. Archived from the original on 5 June 2016. Retrieved 10 December 2016.</ref> It is usually given in combination with other tuberculosis medications, such as isoniazid, rifampicin and [[pyrazinamide]].<ref name="a5">Stuart MC, Kouimtzi M, Hill SR, eds. (2009). WHO Model Formulary 2008. World Health Organization. pp. 136, 138, 588, 603. hdl:10665/44053. ISBN 9789241547659.</ref> It may also be used to treat Mycobacterium avium complex, and Mycobacterium kansasii.<ref name="a4">[https://www.drugs.com/monograph/ethambutol.html "Ethambutol Hydrochloride".] drugs.com. The American Society of Health-System Pharmacists. Archived from the original on 5 June 2016. Retrieved 10 December 2016.</ref> See also [https://en.wikipedia.org/wiki/Ethambutol Ethambutol]. | ||
[[7bvf]] | Ethambutol is bacteriostatic against actively growing TB bacilli. It works by obstructing the formation of cell wall. Mycolic acids attach to the 5'-hydroxyl groups of D-arabinose residues of arabinogalactan and form mycolyl-arabinogalactan-peptidoglycan complex in the cell wall. It disrupts arabinogalactan synthesis by inhibiting the enzyme arabinosyl transferase. Disruption of the arabinogalactan synthesis inhibits the formation of this complex and leads to increased permeability of the cell wall. | ||
<scene name='10/1022091/Cv/2'>Mycobacterium tuberculosis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with ethambutol</scene> ([[7bvf]]). | |||
<scene name='10/1022091/Cv/3'>Ethambutol binding site</scene>. | |||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
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