ATP-citrate synthase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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 == Function ==
-'''ATP-citrate synthase''' (ACS) is part of the citrate cycle.  It catalyzes the transformation of ADP, acetyl-CoA and oxaloacetate to ATP, citrate and CoA.  ACS is the link between energy metabolism from carbohydrates to the production of fatty acids.
+'''ATP-citrate synthase''' (ACS) or '''ATP citrate lyase''' or '''citryl-CoA synthetase''' is part of the citrate cycle.  It catalyzes the transformation of ADP, acetyl-CoA and oxaloacetate to ATP, citrate and CoA.  ACS is the link between energy metabolism from carbohydrates to the production of fatty acids.
+See also [[Citrate Synthase]]<br />
+[[Citric acid cycle intermediates serve as substrates for biosynthetic processes]]<br />
+[[Reverse Krebs cycle]].
-See also [[Citrate Synthase]]
 == Structural highlights ==
-Crystal structures have shown that tartrate and citrate bind to ACS in the same binding site. <scene name='47/477091/Cv/2'>Binding site of tartrate</scene> of ATP-citrate synthase. <scene name='47/477091/Cv/3'>Binding site of ADP and Mg+2 ions</scene> , [[3pff]]. <ref>PMID:22102020</ref>
+Crystal structures have shown that tartrate and citrate bind to ACS in the same binding site. <scene name='47/477091/Cv/4'>Binding site of tartrate</scene> of ATP-citrate synthase. Water molecules are shown as red spheres. <scene name='47/477091/Cv/6'>Binding site of ADP and Mg+2 ions</scene>, [[3pff]]. <ref>PMID:22102020</ref>
-</StructureSection>
 == 3D Structures of ATP-citrate synthase ==
+[[ATP-citrate synthase 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-[[3mwd]], [[5tde]] – hACS + citrate – human<br />
-[[5tdf]], [[5tet]] – hACS + citrate derivative<br />
-[[5teq]] – hACS N-terminal (mutant) + citrate <br />
-[[5te1]] – hACS N-terminal (mutant) + citrate derivative<br />
-[[5tes]] – hACS + citrate + ADP<br />
-[[5tdm]] – hACS + citrate derivative + ADP<br />
-[[3mwe]] – hACS + tartrate<br />
-[[3pff]], [[5tdz]] - hACS + tartrate + ADP<br />
 == References ==
 <references/>
 [[Category:Topic Page]]