ATP-citrate synthase: Difference between revisions

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Michal Harel, Alexander Berchansky

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-{{STRUCTURE_3pff|  PDB=3pff  | SIZE=400| SCENE= |right|CAPTION=ATP-citrate synthase complex with ADP, tartrate and Mg+2 ion, [[3pff]] }}
+<StructureSection load='3pff' size='350' side='right' scene='47/477091/Cv/1' caption='ATP-citrate synthase complex with ADP (stick model), tartrate and Mg+2 ions (green), [[3pff]]'>
-'''ATP-citrate synthase''' (ACS) is part of the citrate cycle.  It catalyzes the transformation of ADP, acetyl-CoA and oxaloacetate to ATP, citrate and CoA.
+== Function ==
-{{TOC limit|limit=2}}
+'''ATP-citrate synthase''' (ACS) or '''ATP citrate lyase''' or '''citryl-CoA synthetase''' is part of the citrate cycle.  It catalyzes the transformation of ADP, acetyl-CoA and oxaloacetate to ATP, citrate and CoA.  ACS is the link between energy metabolism from carbohydrates to the production of fatty acids.
+See also [[Citrate Synthase]]<br />
+[[Citric acid cycle intermediates serve as substrates for biosynthetic processes]]<br />
+[[Reverse Krebs cycle]].
+== Structural highlights ==
+Crystal structures have shown that tartrate and citrate bind to ACS in the same binding site. <scene name='47/477091/Cv/4'>Binding site of tartrate</scene> of ATP-citrate synthase. Water molecules are shown as red spheres. <scene name='47/477091/Cv/6'>Binding site of ADP and Mg+2 ions</scene>, [[3pff]]. <ref>PMID:22102020</ref>
 == 3D Structures of ATP-citrate synthase ==
+[[ATP-citrate synthase 3D structures]]
-[[3mwd]] – hACS + citrate – human<br />
+</StructureSection>
-[[3mwe]] – hACS + tartrate<br />
-[[3pff]] - hACS + tartrate + ADP
+== References ==
+<references/>
 [[Category:Topic Page]]