Diclofenac: Difference between revisions
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<StructureSection load='' size='340' side='right' caption=' | <StructureSection load='' size='340' side='right' caption='Diclofenac' scene='97/974935/Cv/1'> | ||
Diclofenac, sold under the brand name Voltaren, among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammatory diseases such as gout. See also [https://en.wikipedia.org/wiki/Diclofenac]. | Diclofenac, sold under the brand name Voltaren, among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammatory diseases such as gout. See also [https://en.wikipedia.org/wiki/Diclofenac]. | ||
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*Blockage of voltage-dependent sodium channels (after activation of the channel, diclofenac inhibits its reactivation also known as phase inhibition) | *Blockage of voltage-dependent sodium channels (after activation of the channel, diclofenac inhibits its reactivation also known as phase inhibition) | ||
*Blockage of acid-sensing ion channels (ASICs)<ref name="a48">PMID:11588175</ref> | *Blockage of acid-sensing ion channels (ASICs)<ref name="a48">PMID:11588175</ref> | ||
*Positive allosteric modulation of KCNQ- and BK-potassium channels (diclofenac opens these channels, leading to hyperpolarization of the cell membrane) | *Positive allosteric modulation of KCNQ- and BK-potassium channels (diclofenac opens these channels, leading to hyperpolarization of the cell membrane). See [[Potassium Channel]]. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||