2wy0: Difference between revisions

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-==CRYSTAL STRUCTURE OF MOUSE ANGIOTENSINOGEN IN THE OXIDISED FORM WITH SPACE GROUP P6122==
-<StructureSection load='2wy0' size='340' side='right' caption='[[2wy0]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
+==Crystal structure of mouse angiotensinogen in the oxidised form with space group P6122==
+<StructureSection load='2wy0' size='340' side='right'caption='[[2wy0]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2wy0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WY0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WY0 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2wy0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WY0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WY0 FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.38&#8491;</td></tr>
-<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wxz|2wxz]], [[2x0b|2x0b]], [[2wxy|2wxy]], [[2wy1|2wy1]], [[2wxw|2wxw]], [[2wxx|2wxx]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wy0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wy0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wy0 RCSB], [http://www.ebi.ac.uk/pdbsum/2wy0 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wy0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wy0 OCA], [https://pdbe.org/2wy0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wy0 RCSB], [https://www.ebi.ac.uk/pdbsum/2wy0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wy0 ProSAT]</span></td></tr>
-<table>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ANGT_MOUSE ANGT_MOUSE] Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.<ref>PMID:12829792</ref> <ref>PMID:18026570</ref>   Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone (By similarity).<ref>PMID:12829792</ref> <ref>PMID:18026570</ref>   Angiotensin-3: stimulates aldosterone release (By similarity).<ref>PMID:12829792</ref> <ref>PMID:18026570</ref>   Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.<ref>PMID:12829792</ref> <ref>PMID:18026570</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 15: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2wy0" style="background-color:#fffaf0;"></div>
 ==See Also==
-*[[Hormone|Hormone]]
+*[[Serpin 3D structures|Serpin 3D structures]]
-*[[Serpin|Serpin]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Carrell, R W.]]
+[[Category: Carrell RW]]
-[[Category: Read, R J.]]
+[[Category: Read RJ]]
-[[Category: Wei, Z.]]
+[[Category: Wei Z]]
-[[Category: Zhou, A.]]
+[[Category: Zhou A]]
-[[Category: Angiotensin]]
-[[Category: Glycoprotein]]
-[[Category: Hormone]]
-[[Category: Hypertension]]
-[[Category: Renin]]
-[[Category: Serpin]]
-[[Category: Vasoactive]]
-[[Category: Vasoconstrictor]]