DNA polymerase: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| (One intermediate revision by the same user not shown) | |||
| Line 17: | Line 17: | ||
DNA polymerases are some of the most accurate enzymes and have about one mistake for every one billion copies. When a mistake is made, many of the DNA polymerases have the ability to proofread the newly synthesized DNA and correct any mistakes made during replication. The enzymes proofread in the 5'-3' direction. When an error is found, the misplaced nucleotide is cut out so the correct nucleotide can be inserted. This process is often referred to as '''5'-3'exonuclease activity'''. | DNA polymerases are some of the most accurate enzymes and have about one mistake for every one billion copies. When a mistake is made, many of the DNA polymerases have the ability to proofread the newly synthesized DNA and correct any mistakes made during replication. The enzymes proofread in the 5'-3' direction. When an error is found, the misplaced nucleotide is cut out so the correct nucleotide can be inserted. This process is often referred to as '''5'-3'exonuclease activity'''. | ||
==Disease== | |||
Viral DNA polymerase is inhibited by [[Aciclovir]] which is used for treatment of various viral infections. | |||
==Types of DNA Polymerase== | ==Types of DNA Polymerase== | ||
| Line 90: | Line 94: | ||
<scene name='44/440019/Cv/7'>Zn coordination site contains 3 Asp residues</scene> in Family A DNA polymerase I ([[1taq]]).<ref>PMID:7637814</ref> | <scene name='44/440019/Cv/7'>Zn coordination site contains 3 Asp residues</scene> in Family A DNA polymerase I ([[1taq]]).<ref>PMID:7637814</ref> | ||
See also [[Vibriophage phiVC8 DpoZ]] | |||
====DNA Polymerase II==== | ====DNA Polymerase II==== | ||