2wfv: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2wfv.png|left|200px]]
-<!--
+==Crystal structure of DILP5 variant C4==
-The line below this paragraph, containing "STRUCTURE_2wfv", creates the "Structure Box" on the page.
+<StructureSection load='2wfv' size='340' side='right'caption='[[2wfv]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2wfv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WFV FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wfv OCA], [https://pdbe.org/2wfv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wfv RCSB], [https://www.ebi.ac.uk/pdbsum/2wfv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wfv ProSAT]</span></td></tr>
-{{STRUCTURE_2wfv|  PDB=2wfv  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/INSL5_DROME INSL5_DROME]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+We report the crystal structure of two variants of Drosophila melanogaster insulin-like peptide 5 (DILP5) at a resolution of 1.85 A. DILP5 shares the basic fold of the insulin peptide family (T conformation) but with a disordered B-chain C terminus. DILP5 dimerizes in the crystal and in solution. The dimer interface is not similar to that observed in vertebrates, i.e. through an anti-parallel beta-sheet involving the B-chain C termini but, in contrast, is formed through an anti-parallel beta-sheet involving the B-chain N termini. DILP5 binds to and activates the human insulin receptor and lowers blood glucose in rats. It also lowers trehalose levels in Drosophila. Reciprocally, human insulin binds to the Drosophila insulin receptor and induces negative cooperativity as in the human receptor. DILP5 also binds to insect insulin-binding proteins. These results show high evolutionary conservation of the insulin receptor binding properties despite divergent insulin dimerization mechanisms.
-===Crystal structure of DILP5 variant C4===
+Structural and biological properties of the Drosophila insulin-like peptide 5 show evolutionary conservation.,Sajid W, Kulahin N, Schluckebier G, Ribel U, Henderson HR, Tatar M, Hansen BF, Svendsen AM, Kiselyov VV, Norgaard P, Wahlund PO, Brandt J, Kohanski RA, Andersen AS, De Meyts P J Biol Chem. 2011 Jan 7;286(1):661-73. Epub 2010 Oct 25. PMID:20974844<ref>PMID:20974844</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_20974844}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 2wfv" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 20974844 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_20974844}}
+__TOC__
+</StructureSection>
-==About this Structure==
-[[2wfv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFV OCA].
-==Reference==
-<ref group="xtra">PMID:020974844</ref><references group="xtra"/>
 [[Category: Drosophila melanogaster]]
-[[Category: Kulahin, N.]]
+[[Category: Large Structures]]
-[[Category: Meyts, P De.]]
+[[Category: De Meyts P]]
-[[Category: Sajid, W.]]
+[[Category: Kulahin N]]
-[[Category: Schluckebier, G.]]
+[[Category: Sajid W]]
-[[Category: Cleavage on pair of basic residue]]
+[[Category: Schluckebier G]]
-[[Category: Signaling protein]]