2wcq: Difference between revisions

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{{Seed}}
[[Image:2wcq.png|left|200px]]


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==Crystal Structure of Tip-Alpha N34 (HP0596) from Helicobacter pylori at pH4==
The line below this paragraph, containing "STRUCTURE_2wcq", creates the "Structure Box" on the page.
<StructureSection load='2wcq' size='340' side='right'caption='[[2wcq]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2wcq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WCQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WCQ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
{{STRUCTURE_2wcq|  PDB=2wcq  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wcq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wcq OCA], [https://pdbe.org/2wcq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wcq RCSB], [https://www.ebi.ac.uk/pdbsum/2wcq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wcq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/O25318_HELPY O25318_HELPY]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Helicobacter pylori secretes a unique virulence factor, Tipalpha, that enters gastric cells and both stimulates the production of the TNF-alpha and activates the NF-kappaB pathway. The structures of a truncated version of Tipalpha (TipalphaN34) in two crystal forms are presented here. Tipalpha adopts a novel beta(1)alpha(1)alpha(2)beta(2)beta(3)alpha(3)alpha(4) topology that can be described as a combination of three domains. A first region consists in a short flexible extension, a second displays a dodecin-like fold and a third is a helical bundle domain similar to the sterile alpha motif (SAM). Analysis of the oligomerisation states of TipalphaN34 in the crystals and in solution suggests that the disulfide bridges could hold together Tipalpha monomers during their secretion in the gastric environment.


===CRYSTAL STRUCTURE OF TIP-ALPHA N34 (HP0596) FROM HELICOBACTER PYLORI AT PH4===
Structures of the tumor necrosis factor alpha inducing protein Tipalpha: a novel virulence factor from Helicobacter pylori.,Tosi T, Cioci G, Jouravleva K, Dian C, Terradot L FEBS Lett. 2009 May 19;583(10):1581-5. Epub 2009 May 4. PMID:19401200<ref>PMID:19401200</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2wcq" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 19401200 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_19401200}}
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</StructureSection>
==About this Structure==
2WCQ is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WCQ OCA].
 
==Reference==
<ref group="xtra">PMID:19401200</ref><references group="xtra"/>
[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
[[Category: Cioci, G.]]
[[Category: Large Structures]]
[[Category: Dian, C.]]
[[Category: Cioci G]]
[[Category: Jouravleva, K.]]
[[Category: Dian C]]
[[Category: Terradot, L.]]
[[Category: Jouravleva K]]
[[Category: Tosi, T.]]
[[Category: Terradot L]]
[[Category: Helicobacter pylori]]
[[Category: Tosi T]]
[[Category: Hp0596]]
[[Category: Immune system]]
[[Category: Tip-alpha]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 27 14:38:55 2009''

Latest revision as of 15:38, 10 January 2024

Crystal Structure of Tip-Alpha N34 (HP0596) from Helicobacter pylori at pH4Crystal Structure of Tip-Alpha N34 (HP0596) from Helicobacter pylori at pH4

Structural highlights

2wcq is a 2 chain structure with sequence from Helicobacter pylori. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

O25318_HELPY

Publication Abstract from PubMed

Helicobacter pylori secretes a unique virulence factor, Tipalpha, that enters gastric cells and both stimulates the production of the TNF-alpha and activates the NF-kappaB pathway. The structures of a truncated version of Tipalpha (TipalphaN34) in two crystal forms are presented here. Tipalpha adopts a novel beta(1)alpha(1)alpha(2)beta(2)beta(3)alpha(3)alpha(4) topology that can be described as a combination of three domains. A first region consists in a short flexible extension, a second displays a dodecin-like fold and a third is a helical bundle domain similar to the sterile alpha motif (SAM). Analysis of the oligomerisation states of TipalphaN34 in the crystals and in solution suggests that the disulfide bridges could hold together Tipalpha monomers during their secretion in the gastric environment.

Structures of the tumor necrosis factor alpha inducing protein Tipalpha: a novel virulence factor from Helicobacter pylori.,Tosi T, Cioci G, Jouravleva K, Dian C, Terradot L FEBS Lett. 2009 May 19;583(10):1581-5. Epub 2009 May 4. PMID:19401200[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

  1. ↑ Tosi T, Cioci G, Jouravleva K, Dian C, Terradot L. Structures of the tumor necrosis factor alpha inducing protein Tipalpha: a novel virulence factor from Helicobacter pylori. FEBS Lett. 2009 May 19;583(10):1581-5. Epub 2009 May 4. PMID:19401200 doi:10.1016/j.febslet.2009.04.033

2wcq, resolution 1.90Å

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