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==Crystal structure of the RNA-helicase Prp43 from Chaetomium thermophilum bound to ADP== | ==Crystal structure of the RNA-helicase Prp43 from Chaetomium thermophilum bound to ADP== | ||
<StructureSection load='5d0u' size='340' side='right' caption='[[5d0u]], [[Resolution|resolution]] 2.92Å' scene=''> | <StructureSection load='5d0u' size='340' side='right'caption='[[5d0u]], [[Resolution|resolution]] 2.92Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5d0u]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D0U OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[5d0u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D0U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D0U FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.919Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d0u OCA], [https://pdbe.org/5d0u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d0u RCSB], [https://www.ebi.ac.uk/pdbsum/5d0u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d0u ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/G0RY84_CHATD G0RY84_CHATD] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 16: | Line 19: | ||
</div> | </div> | ||
<div class="pdbe-citations 5d0u" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5d0u" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Helicase 3D structures|Helicase 3D structures]] | |||
*[[Pre-mRNA splicing factors 3D structures|Pre-mRNA splicing factors 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Chaetomium thermophilum var. thermophilum DSM 1495]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Ficner R]] | ||
[[Category: | [[Category: Tauchert MJ]] | ||
Latest revision as of 14:23, 10 January 2024
Crystal structure of the RNA-helicase Prp43 from Chaetomium thermophilum bound to ADPCrystal structure of the RNA-helicase Prp43 from Chaetomium thermophilum bound to ADP
Structural highlights
FunctionPublication Abstract from PubMedRNA helicases are indispensable for all organisms in each domain of life and have implications in numerous cellular processes. The DEAH-box RNA helicase Prp43 is involved in pre-mRNA splicing as well as rRNA maturation. Here, the crystal structure of Chaetomium thermophilum Prp43 at 2.9 A resolution is revealed. Furthermore, it is demonstrated that Prp43 from C. thermophilum is capable of functionally replacing its orthologue from Saccharomyces cerevisiae in spliceosomal disassembly assays. Structural and functional analysis of the RNA helicase Prp43 from the thermophilic eukaryote Chaetomium thermophilum.,Tauchert MJ, Fourmann JB, Christian H, Luhrmann R, Ficner R Acta Crystallogr F Struct Biol Commun. 2016 Feb;72(Pt 2):112-20. doi:, 10.1107/S2053230X15024498. Epub 2016 Jan 22. PMID:26841761[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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