5ccs: Difference between revisions

<table><tr><td colspan='2'>[[5ccs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CCS FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C4Y:1-(4-AMINOBENZYL)-3-{2-OXO-2-[(2R)-2-PHENYLPYRROLIDIN-1-YL]ETHYL}UREA'>C4Y</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ccs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ccs OCA], [https://pdbe.org/5ccs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ccs RCSB], [https://www.ebi.ac.uk/pdbsum/5ccs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ccs ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/PPIF_HUMAN PPIF_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probablity of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.<ref>PMID:19228691</ref> <ref>PMID:22726440</ref>  

[[Category: Homo sapiens]]

[[Category: Awais M]]

[[Category: Berry N]]

[[Category: Gibson RP]]

[[Category: Javed A]]

[[Category: Kershaw N]]

[[Category: Latawiec D]]

[[Category: Lian LY]]

[[Category: O'Neill P]]

[[Category: Pandalaneni S]]

[[Category: Shore E]]

[[Category: Sutton R]]

[[Category: Wen L]]