5ap2: Difference between revisions
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<StructureSection load='5ap2' size='340' side='right'caption='[[5ap2]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='5ap2' size='340' side='right'caption='[[5ap2]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5ap2]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5ap2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AP2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AP2 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PWU:ISOPROPYL+6-((4-(1,2-DIMETHYL-1H-IMIDAZOL-5-YL)PHENYL)AMINO)-2-(1-METHYL-1H-PYRAZOL-4-YL)-1H-PYRROLO[3,2-C]PYRIDINE-1-CARBOXYLATE'>PWU</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PWU:ISOPROPYL+6-((4-(1,2-DIMETHYL-1H-IMIDAZOL-5-YL)PHENYL)AMINO)-2-(1-METHYL-1H-PYRAZOL-4-YL)-1H-PYRROLO[3,2-C]PYRIDINE-1-CARBOXYLATE'>PWU</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ap2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ap2 OCA], [https://pdbe.org/5ap2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ap2 RCSB], [https://www.ebi.ac.uk/pdbsum/5ap2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ap2 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Blagg | [[Category: Blagg J]] | ||
[[Category: Boxall | [[Category: Boxall K]] | ||
[[Category: Burke | [[Category: Burke R]] | ||
[[Category: Cheung | [[Category: Cheung KJ]] | ||
[[Category: Faisal | [[Category: Faisal A]] | ||
[[Category: Gurden | [[Category: Gurden MD]] | ||
[[Category: Hoelder | [[Category: Hoelder S]] | ||
[[Category: Linardopoulos | [[Category: Linardopoulos S]] | ||
[[Category: Mak | [[Category: Mak G]] | ||
[[Category: McAndrew | [[Category: McAndrew C]] | ||
[[Category: Naud S]] | |||
[[Category: Naud | [[Category: Schmitt J]] | ||
[[Category: Schmitt | [[Category: Westwood IM]] | ||
[[Category: Westwood | [[Category: Wood A]] | ||
[[Category: Wood | [[Category: Workman P]] | ||
[[Category: Workman | [[Category: Van Montfort RLM]] | ||
[[Category: | |||