5a3r: Difference between revisions

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==Crystal structure of the (SR) Calcium ATPase E2.BeF3- complex bound to TNP-AMPPCP==
==Crystal structure of the (SR) Calcium ATPase E2.BeF3- complex bound to TNP-AMPPCP==
<StructureSection load='5a3r' size='340' side='right' caption='[[5a3r]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
<StructureSection load='5a3r' size='340' side='right'caption='[[5a3r]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5a3r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A3R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A3R FirstGlance]. <br>
<table><tr><td colspan='2'>[[5a3r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A3R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A3R FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DL5:SPIRO(2,4,6-TRINITROBENZENE[1,2A]-O2,O3-METHYLENE-ADENOSINE+(BETA,GAMMA-METHYLENE)TRIPHOSPHATE'>DL5</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.05&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BFD:ASPARTATE+BERYLLIUM+TRIFLUORIDE'>BFD</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BFD:ASPARTATE+BERYLLIUM+TRIFLUORIDE'>BFD</scene>, <scene name='pdbligand=DL5:SPIRO(2,4,6-TRINITROBENZENE[1,2A]-O2,O3-METHYLENE-ADENOSINE+(BETA,GAMMA-METHYLENE)TRIPHOSPHATE'>DL5</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a3q|5a3q]], [[5a3s|5a3s]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a3r OCA], [https://pdbe.org/5a3r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a3r RCSB], [https://www.ebi.ac.uk/pdbsum/5a3r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a3r ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium-transporting_ATPase Calcium-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.8 3.6.3.8] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a3r OCA], [http://pdbe.org/5a3r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a3r RCSB], [http://www.ebi.ac.uk/pdbsum/5a3r PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/AT2A1_RABIT AT2A1_RABIT]] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction (By similarity).  
[https://www.uniprot.org/uniprot/AT2A1_RABIT AT2A1_RABIT] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5a3r" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5a3r" style="background-color:#fffaf0;"></div>
==See Also==
*[[ATPase 3D structures|ATPase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Calcium-transporting ATPase]]
[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
[[Category: Andersen, J P]]
[[Category: Andersen JP]]
[[Category: Arnou, B]]
[[Category: Arnou B]]
[[Category: Bublitz, M]]
[[Category: Bublitz M]]
[[Category: Clausen, J D]]
[[Category: Clausen JD]]
[[Category: Moller, J V]]
[[Category: Moller JV]]
[[Category: Nissen, P]]
[[Category: Nissen P]]
[[Category: Olesen, C]]
[[Category: Olesen C]]
[[Category: Beryllium fluoride]]
[[Category: Calcium transport]]
[[Category: Hydrolase]]
[[Category: Inhibition]]
[[Category: P-type atpase]]
[[Category: Serca]]
[[Category: Tnp-amppcp]]
[[Category: Transition state]]
[[Category: Trinitrophenyl-nucleotide analoge]]

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