4y71: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
-The entry 4y71 is ON HOLD
+==Factor Xa complex with GTC000398==
+<StructureSection load='4y71' size='340' side='right'caption='[[4y71]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4y71]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y71 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y71 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=48W:6-CHLORO-N-{(3S)-1-[(2S)-1-(4-METHYL-5-OXO-1,4-DIAZEPAN-1-YL)-1-OXOPROPAN-2-YL]-2-OXOPYRROLIDIN-3-YL}NAPHTHALENE-2-SULFONAMIDE'>48W</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y71 OCA], [https://pdbe.org/4y71 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y71 RCSB], [https://www.ebi.ac.uk/pdbsum/4y71 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y71 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
-Authors: Convery, M.A., Young, R.J., Senger, S., Hamblin, J.N., Chan, C., Toomey, J.R., Watson, N.S.
+==See Also==
+*[[Factor Xa|Factor Xa]]
-Description:
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Senger, S]]
+__TOC__
-[[Category: Toomey, J.R]]
+</StructureSection>
-[[Category: Hamblin, J.N]]
+[[Category: Homo sapiens]]
-[[Category: Watson, N.S]]
+[[Category: Large Structures]]
-[[Category: Young, R.J]]
+[[Category: Chan C]]
-[[Category: Convery, M.A]]
+[[Category: Convery MA]]
-[[Category: Chan, C]]
+[[Category: Hamblin JN]]
+[[Category: Senger S]]
+[[Category: Toomey JR]]
+[[Category: Watson NS]]
+[[Category: Young RJ]]