4x6h: Difference between revisions

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 ==Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors.==
-<StructureSection load='4x6h' size='340' side='right' caption='[[4x6h]], [[Resolution|resolution]] 1.00&Aring;' scene=''>
+<StructureSection load='4x6h' size='340' side='right'caption='[[4x6h]], [[Resolution|resolution]] 1.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4x6h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X6H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X6H FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4x6h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X6H FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3XT:4-AMINO-3-FLUORO-N-(1-{[(2Z)-2-IMINOETHYL]CARBAMOYL}CYCLOHEXYL)BENZAMIDE'>3XT</scene>, <scene name='pdbligand=I37:4-AMINO-N-{1-[(CYANOMETHYL)CARBAMOYL]CYCLOHEXYL}-3-FLUOROBENZAMIDE'>I37</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSK, CTSO, CTSO2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3XT:4-AMINO-3-FLUORO-N-(1-{[(2Z)-2-IMINOETHYL]CARBAMOYL}CYCLOHEXYL)BENZAMIDE'>3XT</scene>, <scene name='pdbligand=I37:4-AMINO-N-{1-[(CYANOMETHYL)CARBAMOYL]CYCLOHEXYL}-3-FLUOROBENZAMIDE'>I37</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x6h OCA], [https://pdbe.org/4x6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x6h RCSB], [https://www.ebi.ac.uk/pdbsum/4x6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x6h ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x6h OCA], [http://pdbe.org/4x6h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x6h RCSB], [http://www.ebi.ac.uk/pdbsum/4x6h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x6h ProSAT]</span></td></tr>
 </table>
 == Disease ==
-[[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[http://omim.org/entry/265800 265800]]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref>
+[https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[https://omim.org/entry/265800 265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref>
 == Function ==
-[[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
+[https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 22: / Line 21: @@
 </div>
 <div class="pdbe-citations 4x6h" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Cathepsin 3D structures|Cathepsin 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Cathepsin K]]
+[[Category: Homo sapiens]]
-[[Category: Human]]
+[[Category: Large Structures]]
-[[Category: Borisek, J]]
+[[Category: Borisek J]]
-[[Category: Mohar, B]]
+[[Category: Mohar B]]
-[[Category: Novic, M]]
+[[Category: Novic M]]
-[[Category: Sosnowski, P]]
+[[Category: Sosnowski P]]
-[[Category: Turk, B]]
+[[Category: Turk B]]
-[[Category: Turk, D]]
+[[Category: Turk D]]
-[[Category: Vizovisek, M]]
+[[Category: Vizovisek M]]
-[[Category: Cathepsin k]]
-[[Category: Hydrolase]]
-[[Category: Inhibitor]]