4v2e: Difference between revisions
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==FLRT3 LRR domain== | ==FLRT3 LRR domain== | ||
<StructureSection load='4v2e' size='340' side='right' caption='[[4v2e]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='4v2e' size='340' side='right'caption='[[4v2e]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4v2e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V2E OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4v2e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V2E FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v2e OCA], [https://pdbe.org/4v2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v2e RCSB], [https://www.ebi.ac.uk/pdbsum/4v2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v2e ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/FLRT3_MOUSE FLRT3_MOUSE] Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners (PubMed:19056886, PubMed:25374360). Plays a role in the spatial organization of brain neurons (PubMed:25374360). Plays a role in vascular development in the retina (PubMed:25374360). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:22405201, PubMed:25374360). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (PubMed:21673655, PubMed:25374360). Promotes neurite outgrowth (in vitro) (By similarity). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length (By similarity). Plays a role in the regulation of the density of glutamaergic synapses (PubMed:22405201). Plays a role in fibroblast growth factor-mediated signaling cascades (PubMed:16872596). Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning (PubMed:19056886). Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development (PubMed:18448090). Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (PubMed:19056886).[UniProtKB:B1H234]<ref>PMID:16872596</ref> <ref>PMID:18448090</ref> <ref>PMID:19056886</ref> <ref>PMID:21673655</ref> <ref>PMID:22405201</ref> <ref>PMID:24560577</ref> <ref>PMID:25374360</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4v2e" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Acker-Palmer | [[Category: Large Structures]] | ||
[[Category: Border | [[Category: Mus musculus]] | ||
[[Category: Cop | [[Category: Acker-Palmer A]] | ||
[[Category: Haertl | [[Category: Border EC]] | ||
[[Category: Harlos | [[Category: Cop F]] | ||
[[Category: Jones | [[Category: Haertl R]] | ||
[[Category: Klein | [[Category: Harlos K]] | ||
[[Category: Nagel | [[Category: Jones EY]] | ||
[[Category: Ruff | [[Category: Klein R]] | ||
[[Category: Seiradake | [[Category: Nagel D]] | ||
[[Category: Seyit-Bremer | [[Category: Ruff T]] | ||
[[Category: Toro | [[Category: Seiradake E]] | ||
[[Category: Seyit-Bremer G]] | |||
[[Category: Del Toro D]] | |||