4uwm: Difference between revisions

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 <StructureSection load='4uwm' size='340' side='right'caption='[[4uwm]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4uwm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_fluorescens_putidus"_flugge_1886 "bacillus fluorescens putidus" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UWM FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4uwm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UWM FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uwm OCA], [http://pdbe.org/4uwm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uwm RCSB], [http://www.ebi.ac.uk/pdbsum/4uwm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uwm ProSAT]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uwm OCA], [https://pdbe.org/4uwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uwm RCSB], [https://www.ebi.ac.uk/pdbsum/4uwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uwm ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/C16MO_PSEPU C16MO_PSEPU]] Involved in the degradation of (-)-camphor. Catalyzes the lactonization of the 3,6-diketocamphane via the Baeyer-Villiger oxidation to produce the unstable lactone (-)-5-oxo-1,2-campholide that presumably undergoes spontaneous hydrolysis to form 2-oxo-delta(3)-4,5,5-trimethylcyclopentenylacetic acid. It acts only on bicyclic ketones.<ref>PMID:22286514</ref> <ref>PMID:8515237</ref>
+[https://www.uniprot.org/uniprot/36DKM_PSEPU 36DKM_PSEPU] Involved in the degradation and assimilation of (-)-camphor, which allows P.putida strain NCIMB 10007 to grow on this enantiomer of camphor as the sole carbon source (PubMed:8515237). Catalyzes the FMNH(2)-dependent lactonization of 3,6-diketocamphane via a Baeyer-Villiger oxidation to produce the unstable lactone 5-oxo-1,2-campholide with (S,S) configuration, that presumably undergoes spontaneous hydrolysis to form 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetate (PubMed:23524667). Is also able to convert (-)-camphor to the corresponding lactone in vitro (PubMed:23524667, PubMed:22286514, PubMed:8515237). Shows no conversion of (+)-camphor, (+)-fenchone, (-)-fenchone, and (+)-nopinone. Acts on other bicyclic ketones but very poorly on a few 2- and 4-substituted monocyclic ketones (PubMed:23524667).<ref>PMID:22286514</ref> <ref>PMID:23524667</ref> <ref>PMID:8515237</ref> <ref>PMID:8515237</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 __TOC__
 </StructureSection>
-[[Category: Bacillus fluorescens putidus flugge 1886]]
 [[Category: Large Structures]]
-[[Category: Beecher, J]]
+[[Category: Pseudomonas putida]]
-[[Category: Bornscheuer, U T]]
+[[Category: Beecher J]]
-[[Category: Bourenkov, G]]
+[[Category: Bornscheuer UT]]
-[[Category: Davenport, C F]]
+[[Category: Bourenkov G]]
-[[Category: Dcunha, S]]
+[[Category: Davenport CF]]
-[[Category: Donadio, G]]
+[[Category: Dcunha S]]
-[[Category: Gibson, R P]]
+[[Category: Donadio G]]
-[[Category: Hasegawa, Y]]
+[[Category: Gibson RP]]
-[[Category: Isupov, M N]]
+[[Category: Hasegawa Y]]
-[[Category: Iwaki, H]]
+[[Category: Isupov MN]]
-[[Category: Kadow, M]]
+[[Category: Iwaki H]]
-[[Category: Lau, P C]]
+[[Category: Kadow M]]
-[[Category: Littlechild, J A]]
+[[Category: Lau PC]]
-[[Category: Loschinski, K]]
+[[Category: Littlechild JA]]
-[[Category: McGhie, E J]]
+[[Category: Loschinski K]]
-[[Category: Saneei, V]]
+[[Category: McGhie EJ]]
-[[Category: Sayer, C]]
+[[Category: Saneei V]]
-[[Category: Schroeder, E]]
+[[Category: Sayer C]]
-[[Category: Biocatalysis]]
+[[Category: Schroeder E]]
-[[Category: Oxidoreductase]]