4utp: Difference between revisions

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 ==Crystal structure of pneumococcal surface antigen PsaA in the Cd- bound, closed state==
-<StructureSection load='4utp' size='340' side='right' caption='[[4utp]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+<StructureSection load='4utp' size='340' side='right'caption='[[4utp]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4utp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UTP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UTP FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4utp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UTP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UTP FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene><br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uto|4uto]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4utp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4utp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4utp RCSB], [http://www.ebi.ac.uk/pdbsum/4utp PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4utp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4utp OCA], [https://pdbe.org/4utp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4utp RCSB], [https://www.ebi.ac.uk/pdbsum/4utp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4utp ProSAT]</span></td></tr>
-<table>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MTSA_STRPN MTSA_STRPN] Part of an ATP-driven transport system for manganese. Also act as an adhesin which is involved on adherence to extracellular matrix. It is an important factor in pathogenesis and infection.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Cadmium is a transition metal ion that is highly toxic in biological systems. Although relatively rare in the Earth's crust, anthropogenic release of cadmium since industrialization has increased biogeochemical cycling and the abundance of the ion in the biosphere. Despite this, the molecular basis of its toxicity remains unclear. Here we combine metal-accumulation assays, high-resolution structural data and biochemical analyses to show that cadmium toxicity, in Streptococcus pneumoniae, occurs via perturbation of first row transition metal ion homeostasis. We show that cadmium uptake reduces the millimolar cellular accumulation of manganese and zinc, and thereby increases sensitivity to oxidative stress. Despite this, high cellular concentrations of cadmium (~17 mM) are tolerated, with negligible impact on growth or sensitivity to oxidative stress, when manganese and glutathione are abundant. Collectively, this work provides insight into the molecular basis of cadmium toxicity in prokaryotes, and the connection between cadmium accumulation and oxidative stress.
+Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae.,Begg SL, Eijkelkamp BA, Luo Z, Counago RM, Morey JR, Maher MJ, Ong CL, McEwan AG, Kobe B, O'Mara ML, Paton JC, McDevitt CA Nat Commun. 2015 Mar 3;6:6418. doi: 10.1038/ncomms7418. PMID:25731976<ref>PMID:25731976</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 4utp" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Adhesin 3D structures|Adhesin 3D structures]]
+== References ==
+<references/>
 __TOC__
 </StructureSection>
-[[Category: Counago, R M.]]
+[[Category: Large Structures]]
-[[Category: Luo, Z.]]
+[[Category: Streptococcus pneumoniae]]
-[[Category: Maher, M.]]
+[[Category: Counago RM]]
-[[Category: Kobe, B.]]
+[[Category: Kobe B]]
-[[Category: Atp binding]]
+[[Category: Luo Z]]
-[[Category: Cassette transporter]]
+[[Category: Maher M]]
-[[Category: Metal binding protein]]