8fvu: Difference between revisions
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==Cryo-EM structure of human Needle/NAIP/NLRC4 (R288A)== | |||
<StructureSection load='8fvu' size='340' side='right'caption='[[8fvu]], [[Resolution|resolution]] 3.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8fvu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis], [https://en.wikipedia.org/wiki/Burkholderia Burkholderia] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FVU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FVU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fvu OCA], [https://pdbe.org/8fvu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fvu RCSB], [https://www.ebi.ac.uk/pdbsum/8fvu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fvu ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/BIRC1_HUMAN BIRC1_HUMAN] Proximal spinal muscular atrophy type 2;Proximal spinal muscular atrophy type 1;Proximal spinal muscular atrophy type 3. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BIRC1_HUMAN BIRC1_HUMAN] Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy. Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bacillus anthracis]] | |||
[[Category: Burkholderia]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Berger S]] | |||
[[Category: Faustin B]] | |||
[[Category: Kumar N]] | |||
[[Category: Matico RE]] | |||
[[Category: Medley Q]] | |||
[[Category: Miller R]] | |||
[[Category: Ricketts MD]] | |||
[[Category: Sharma S]] | |||
[[Category: Somani S]] | |||
[[Category: Steele RA]] | |||
[[Category: Yu X]] | |||
Latest revision as of 14:01, 3 January 2024
Cryo-EM structure of human Needle/NAIP/NLRC4 (R288A)Cryo-EM structure of human Needle/NAIP/NLRC4 (R288A)
Structural highlights
DiseaseBIRC1_HUMAN Proximal spinal muscular atrophy type 2;Proximal spinal muscular atrophy type 1;Proximal spinal muscular atrophy type 3. FunctionBIRC1_HUMAN Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy. Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila. |
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