5ou9: Difference between revisions
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The entry | ==Crystal structure of Glycoprotein VI in complex with collagen-peptide (GPO)3== | ||
<StructureSection load='5ou9' size='340' side='right'caption='[[5ou9]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5ou9]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OU9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OU9 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ou9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ou9 OCA], [https://pdbe.org/5ou9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ou9 RCSB], [https://www.ebi.ac.uk/pdbsum/5ou9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ou9 ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/GPVI_HUMAN GPVI_HUMAN] Bleeding diathesis due to glycoprotein VI deficiency. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GPVI_HUMAN GPVI_HUMAN] Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.<ref>PMID:10961879</ref> <ref>PMID:18955485</ref> | |||
==See Also== | |||
*[[Platelet glycoprotein|Platelet glycoprotein]] | |||
== References == | |||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Feitsma LJ]] | |||
[[Category: Huizinga EG]] | |||
Latest revision as of 04:24, 28 December 2023
Crystal structure of Glycoprotein VI in complex with collagen-peptide (GPO)3Crystal structure of Glycoprotein VI in complex with collagen-peptide (GPO)3
Structural highlights
DiseaseGPVI_HUMAN Bleeding diathesis due to glycoprotein VI deficiency. The disease is caused by mutations affecting the gene represented in this entry. FunctionGPVI_HUMAN Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.[1] [2] See AlsoReferences
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