2v6q: Difference between revisions

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-{{Seed}}
-[[Image:2v6q.png|left|200px]]
-<!--
+==Crystal Structure of a BHRF-1 : Bim BH3 complex==
-The line below this paragraph, containing "STRUCTURE_2v6q", creates the "Structure Box" on the page.
+<StructureSection load='2v6q' size='340' side='right'caption='[[2v6q]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2v6q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_4 Human gammaherpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V6Q FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
-{{STRUCTURE_2v6q|  PDB=2v6q  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v6q OCA], [https://pdbe.org/2v6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v6q RCSB], [https://www.ebi.ac.uk/pdbsum/2v6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v6q ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/EAR_EBVG EAR_EBVG] Prevents premature death of the host cell during virus production, which would otherwise reduce the amount of progeny virus. Acts as a host B-cell leukemia/lymphoma 2 (Bcl-2) homolog, and interacts with pro-apoptotic proteins to prevent mitochondria permeabilization, release of cytochrome c and subsequent apoptosis of the host cell (By similarity).
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Epstein-Barr virus (EBV) is associated with human malignancies, especially those affecting the B cell compartment such as Burkitt lymphoma. The virally encoded homolog of the mammalian pro-survival protein Bcl-2, BHRF1 contributes to viral infectivity and lymphomagenesis. In addition to the pro-apoptotic BH3-only protein Bim, its key target in lymphoid cells, BHRF1 also binds a selective sub-set of pro-apoptotic proteins (Bid, Puma, Bak) expressed by host cells. A consequence of BHRF1 expression is marked resistance to a range of cytotoxic agents and in particular, we show that its expression renders a mouse model of Burkitt lymphoma untreatable. As current small organic antagonists of Bcl-2 do not target BHRF1, the structures of it in complex with Bim or Bak shown here will be useful to guide efforts to target BHRF1 in EBV-associated malignancies, which are usually associated with poor clinical outcomes.
-===CRYSTAL STRUCTURE OF A BHRF-1 : BIM BH3 COMPLEX===
+Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus BHRF1.,Kvansakul M, Wei AH, Fletcher JI, Willis SN, Chen L, Roberts AW, Huang DC, Colman PM PLoS Pathog. 2010 Dec 23;6(12):e1001236. PMID:21203485<ref>PMID:21203485</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-==About this Structure==
+</div>
-V6Q is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V6Q OCA].
+<div class="pdbe-citations 2v6q" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Human herpesvirus 4]]
+[[Category: Human gammaherpesvirus 4]]
-[[Category: Colman, P M.]]
+[[Category: Large Structures]]
-[[Category: Huang, D C.S.]]
+[[Category: Colman PM]]
-[[Category: Kvansakul, M.]]
+[[Category: Huang DCS]]
-[[Category: Alternative splicing]]
+[[Category: Kvansakul M]]
-[[Category: Apoptosis]]
-[[Category: Bcl-2]]
-[[Category: Membrane]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 13 13:23:22 2010''