4xuu: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
Line 4: Line 4:
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4xuu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XUU FirstGlance]. <br>
<table><tr><td colspan='2'>[[4xuu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XUU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.62&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xuu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xuu OCA], [https://pdbe.org/4xuu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xuu RCSB], [https://www.ebi.ac.uk/pdbsum/4xuu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xuu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xuu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xuu OCA], [https://pdbe.org/4xuu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xuu RCSB], [https://www.ebi.ac.uk/pdbsum/4xuu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xuu ProSAT]</span></td></tr>
</table>
</table>

Latest revision as of 03:55, 28 December 2023

The hSac2 domain from human phosphoinositide phosphatase Sac2The hSac2 domain from human phosphoinositide phosphatase Sac2

Structural highlights

4xuu is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.62Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SAC2_HUMAN Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Hydrolyzes phosphatidylinositol 4,5-bisphosphate most effectively. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation.[1] [2]

See Also

References

  1. ↑ Minagawa T, Ijuin T, Mochizuki Y, Takenawa T. Identification and characterization of a sac domain-containing phosphoinositide 5-phosphatase. J Biol Chem. 2001 Jun 22;276(25):22011-5. Epub 2001 Mar 26. PMID:11274189 doi:http://dx.doi.org/10.1074/jbc.M101579200
  2. ↑ Trivedi CM, Luo Y, Yin Z, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA. Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. Nat Med. 2007 Mar;13(3):324-31. Epub 2007 Feb 18. PMID:17322895 doi:http://dx.doi.org/nm1552

4xuu, resolution 2.62Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=4xuu&oldid=4010712"