4whw: Difference between revisions

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-'''Unreleased structure'''
-The entry 4whw is ON HOLD
+==Direct photocapture of bromodomains using tropolone chemical probes==
+<StructureSection load='4whw' size='340' side='right'caption='[[4whw]], [[Resolution|resolution]] 1.34&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4whw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WHW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WHW FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.345&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3OT:2-METHOXY-4-{1-[2-(MORPHOLIN-4-YL)ETHYL]-2-(2-PHENYLETHYL)-1H-BENZIMIDAZOL-5-YL}CYCLOHEPTA-2,4,6-TRIEN-1-ONE'>3OT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4whw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4whw OCA], [https://pdbe.org/4whw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4whw RCSB], [https://www.ebi.ac.uk/pdbsum/4whw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4whw ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
-Authors: Erik C. Hett, Eugene L. Piatnitski Chekler, Arindrajit Basak,b Paul D. Bonin,c R. Aldrin Denny,a Andrew C. Flick,b Kieran F. Geoghegan,d Shenping Liu,d Mathew T. Pletcher,e Ralph P. Robinson,b Parag Sahasrabudhe,d Shores Salter,a Ingrid A. Stockc and Lyn H. Jones
+==See Also==
+*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
-Description: Direct photocapture of bromodomains using tropolone chemical probes
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Basak A]]
+[[Category: Bonin PD]]
+[[Category: Denny RA]]
+[[Category: Flick AC]]
+[[Category: Geoghegan KF]]
+[[Category: Hett EC]]
+[[Category: Jones LH]]
+[[Category: Liu S]]
+[[Category: Piatnitski Chekler EL]]
+[[Category: Pletcher MT]]
+[[Category: Robinson RP]]
+[[Category: Sahasrabudhe P]]
+[[Category: Salter S]]
+[[Category: Stock IA]]