4tlm: Difference between revisions

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 ==Crystal structure of GluN1/GluN2B NMDA receptor, structure 2==
-<StructureSection load='4tlm' size='340' side='right' caption='[[4tlm]], [[Resolution|resolution]] 3.77&Aring;' scene=''>
+<StructureSection load='4tlm' size='340' side='right'caption='[[4tlm]], [[Resolution|resolution]] 3.77&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4tlm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TLM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TLM FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4tlm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TLM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TLM FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1AC:1-AMINOCYCLOPROPANECARBOXYLIC+ACID'>1AC</scene>, <scene name='pdbligand=JEG:TRANS-1-AMINOCYCLOBUTANE-1,3-DICARBOXYLIC+ACID'>JEG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=QEM:4-[(1R,2S)-3-(4-BENZYLPIPERIDIN-1-YL)-1-HYDROXY-2-METHYLPROPYL]PHENOL'>QEM</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.77&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4tll|4tll]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1AC:1-AMINOCYCLOPROPANECARBOXYLIC+ACID'>1AC</scene>, <scene name='pdbligand=JEG:TRANS-1-AMINOCYCLOBUTANE-1,3-DICARBOXYLIC+ACID'>JEG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=QEM:4-[(1R,2S)-3-(4-BENZYLPIPERIDIN-1-YL)-1-HYDROXY-2-METHYLPROPYL]PHENOL'>QEM</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tlm OCA], [http://pdbe.org/4tlm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tlm RCSB], [http://www.ebi.ac.uk/pdbsum/4tlm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tlm ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tlm OCA], [https://pdbe.org/4tlm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tlm RCSB], [https://www.ebi.ac.uk/pdbsum/4tlm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tlm ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/NMDZ1_XENLA NMDZ1_XENLA] Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:16214956, PubMed:19524674, PubMed:21677647, PubMed:25008524, PubMed:26912815, PubMed:27135925, Ref.11, PubMed:28232581). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable).<ref>PMID:16214956</ref> <ref>PMID:19524674</ref> <ref>PMID:21677647</ref> <ref>PMID:25008524</ref> <ref>PMID:26912815</ref> <ref>PMID:27135925</ref> <ref>PMID:28232581</ref> [PDB:5IOV]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 21: @@
 ==See Also==
-*[[Ionotropic Glutamate Receptors|Ionotropic Glutamate Receptors]]
+*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Gouaux, E]]
+[[Category: Large Structures]]
-[[Category: Lee, C H]]
+[[Category: Xenopus laevis]]
-[[Category: Lu, W]]
+[[Category: Gouaux E]]
-[[Category: Glun1/glun2b]]
+[[Category: Lee C-H]]
-[[Category: Ion channel]]
+[[Category: Lu W]]
-[[Category: Membrane protein]]
-[[Category: Neurotransmitter receptor]]
-[[Category: Nmda receptor]]
-[[Category: Signaling protein]]