4pd3: Difference between revisions

<StructureSection load='4pd3' size='340' side='right'caption='[[4pd3]], [[Resolution|resolution]] 2.84&Aring;' scene=''>

<table><tr><td colspan='2'>[[4pd3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PD3 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.84&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pd3 OCA], [https://pdbe.org/4pd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pd3 RCSB], [https://www.ebi.ac.uk/pdbsum/4pd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pd3 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/ACTNA_DICDI ACTNA_DICDI] F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Increases the actin-stimulated ATPase activity of myosin. Involved in vegetative cell growth, phagocytosis, motility and development, probably through stabilization of the actin network in the cortical cytoskeleton.<ref>PMID:10411959</ref> <ref>PMID:10413681</ref> <ref>PMID:10704840</ref> <ref>PMID:1732064</ref> <ref>PMID:3956480</ref> <ref>PMID:6746725</ref> <ref>PMID:8486739</ref> <ref>PMID:8937986</ref> [https://www.uniprot.org/uniprot/MYH10_HUMAN MYH10_HUMAN] Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9.<ref>PMID:20052411</ref> <ref>PMID:20603131</ref>  

[[Category: Dictyostelium discoideum]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Manstein DJ]]

[[Category: Munnich S]]

[[Category: Pathan-Chhatbar S]]